dermatology by vale- cause e fattori di rischio

What are the main risk factors for developing cutaneous squamous cell carcinoma cSCC?

• chronic UV exposure

• fair skin type (Fitzpatrick type I and II)

• immunosoppression

• genetic disorders (xeroderma pigmentosum)

• HPV infection (16,18- especially for gential and oropharyngeal SCC)

Endogenous risk factors for melanoma:

• Fair skin type

• family or personal history of melanoma

• numerous nevi

• atypical nevi

• CMN congenital melanocytic nevi with more than 20 cm diameter

• genetic germline mutations (CDKN2A, CDK4 genes)

• MC1R gene variants

Exogenous risk factors for melanoma:

• chronic UV exposure

• artificial UV exposure

• iatrogenic immunosuppression

• geographical and environmental factors

Describe anonichia and 2 pathologies that cause it:

“ENIL”= patologie

• Epidermolysis bullosa dystrophica

• Nail patellar syndrome

• Irritant contact paronychia

• Lichen ruber planus

Define onichodynia and 4 causes of this condition:

Cause

• Trauma

• Infection

• Psoriasis

• Subungual tumor especially glomic tumors

• Raynaud’s Syndrome

Define onycholysis and 3 causes:

Separation of nail palte from nail bed

Causes:

• Trauma- repetitive

• Onychomicosis

• Psoriasis

4 conditions with nail curvature:

• Tile shaped nails

• Pincer nails

• Parrot beak nails

• Clubbed nails