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Who found platinum analogs
rosenburg
What did rosenburg think cell division was controlled by
electrical field
what drug did rosenburg discover
cisplatin
what are two drug derivatives of cisplatin
oxoplatin carboplatin
used for head and neck and testicular cancer
cisplatin
most commonly used platinum analog
cisplatin
symtoms of cisplatin
GI, nausea, myeolsuppression
carboplatin is more toxic to
bone marrow
ovarian cancer is used to treat
ovarian and lung
Oxoplatin is used to treat
colorectal cancer
How do platins work
form DNA adducts
what do platins react with
N7 on guanine
What type of crosslinks do platins make
intrastrand or interstrand
oxoplaltin may cause
ribosome dysfunction thriugh translation block
DNA repair initiated is mainly
dna excision repair
substantial adducts could lead to
single or double-stranded breaks
