BENG 166A Cell & Tissue Engineering

Flashcards for BENG 166A covering key concepts in Cell & Tissue Engineering.

What is the focus of BENG 166A Cell & Tissue Engineering?

Engineering analysis of physico-chemical processes affecting cells and tissues.

What are some key processes studied in Cell & Tissue Engineering?

Cell migration, mitosis, apoptosis, differentiation.

What are mesenchyme and parenchyme in tissue engineering?

Mesenchyme refers to the connective tissue, while parenchyme refers to the functional tissue in an organ.

What does the tissue microenvironment encompass?

Cell-cell interactions, extracellular matrix, and growth factor communication.

What are the prerequisites for enrolling in BENG 166A?

BENG 103B or BENG 112B and senior standing or consent of the department.

How does Tissue Engineering differ from Regenerative Medicine?

Tissue Engineering focuses on developing substitutes; Regenerative Medicine aims to restore tissue function.

What year did Prof. Fung coin the phrase 'Tissue Engineering'?

1987.

What are some major approaches in Tissue Engineering?

1. Implanting tissue-inducing substances 2. Using isolated or cultured cells 3. Forming tissues/organs in vitro.

What are fibroblasts responsible for in tissues?

Producing extracellular matrix components like collagen and fibronectin.

What role do chondrocytes play in cartilage?

Producing and maintaining the extracellular matrix, enabling joint movement.

In what ways can stem cells be utilized in cardiac cell therapy?

When functional cells are unavailable, sources include bone marrow and adipose-derived stem cells.

Define the term 'medical device' in the context of tissue engineering.

An instrument or implant used to diagnose, prevent, or treat disease.

What is the regulatory classification of medical devices by the FDA?

FDA risk Class I, II, III.

What is the importance of the extracellular matrix (ECM) in tissue engineering?

It provides structural support and regulates tissue functions.

What is the significance of cell-cell interactions in the tissue microenvironment?

They are critical for maintaining tissue homeostasis and functionality.

What biological components do cells need to perform effectively in tissue engineering?

Nutrients, signals from the ECM, and interactions with other cell types.

How does regenerative medicine relate to successful tissue healing?

It utilizes therapies that aim to restore and improve tissue functions.