Neurogenesis in the Human Hippocampus

Subgranular zone

Region in dentate gyrus linked to neurogenesis.

Dentate gyrus

Part of hippocampus involved in memory and learning.

BrdU administration

Method to label dividing cells in tissues.

Immunohistochemistry

Technique for detecting proteins in cells.

Fluorescent microscopy

Imaging technique using fluorescence to visualize samples.

Electron microscopy

High-resolution imaging technique for cellular structures.

RNAscope

In situ hybridization method for RNA detection.

Comparative gene transcription analysis

Method to compare gene expression across samples.

Ki-67

Marker indicating cell proliferation.

SOX1/SOX2

Transcription factors for neural progenitor cells.

DCX+PSA-NCAM

Markers for young neurons.

BLBP

Marker for radial glia cells.

Nestin

Marker for neural precursor cells.

Vimentin

Intermediate filament protein in precursor cells.

GFAP

Astrocyte marker indicating glial cells.

ALDH1L1

Marker for astrocytes in the brain.

NeuN

Marker for mature neuronal nuclei.

TUJ1

Marker for neural cells.

PSA-NCAM

Marker for young neurons in development.

Dividing progenitor cells

Cells that give rise to new neurons.

Neurogenesis

Process of generating new neurons.

Mature neurons

Fully developed neurons with established functions.

Young neurons

Recently formed neurons still maturing.

Dividing cells

Cells undergoing mitosis or division.