Cell Biology Lecture 14: DNA Heredity, Structure and Replication

Griffith Experiment Condition #1

Live S strain live S strain from blood mouse dies

Griffith Experiment Condition #2

Mouse lives, few live R strain from blood

Griffith Experiment Condition #3

Heat killed s strain, mouse lives no live cells

Griffith Experiment Condition #4

live R plus heat killed S strian, mouse dies, live s strain from blood 

Avery Macleod and McCarthy Experiment

heat killed s strain and live R plus one of the enzymes 

Conclusion of Avery Macleod and McCarthy Experiment

DNA is the genetic material

What is DNA

polymer made up of A T G and C

Chargaff Rules

Base pairing rules

Fraklin discoveries on DNA

DNA is a double helix, 10 nucleotides per turn

Watson and Crick discoveries on DNA

strands are antiparallel, base pairs based on Hbonding, General mechanism for replication, parent strands acting as template for daughter strands. 

What does adding an acetyl group do

loosen DNA from histone

What does adding methyl group do

condenses DNA

Heterochromatin

Condensed Chromosomes

Euchromatin

Uncondensed chromatin