Oxidative Stress and Ischemia-Reperfusion

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7 Terms

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What can cause Oxydative Stress

ROS

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Production of ROS (2)

  1. Mitochondria during ATP production

  2. Neutrophils and macrophages

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Removal of ROS (3)

  1. Spontaneous decay

  2. Enzymes

  3. Antioxidants

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What can increase ROS and cause oxidative stress (too much ROS)? (3)

  1. Infection

    1. Activation of inflammatory cells to destroy microbes

  2. Ionizing radiation and some chemicals

  3. Ischemia-reperfusion injury

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How does increased ROS cause cell injury?

  1. Lipid peroxidation

  2. Single-stranded DNA breaks

  3. Cross-link or fragment proteins

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What does lipid peroxidation do? (2)

  1. Damage membranes

  2. Reversible then necrosis

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What does Cross-link or fragment proteins do? (3)

  1. Increase protein degradation (structural proteins and enzymes)

  2. Protein misfolding

  3. Irreversible