Untitled Flashcards Set

Hypotensive side effect from antipsychotic

Alpha-1 adrenergic receptor blockade.

Constipation and dry mouth from antipsychotic

M3 receptor blockade affects smooth muscle.

Sedation side effect from antipsychotic

H1 receptor antagonism

Neuroleptic Malignant Syndrome/ irregular periods

Caused by D2 receptor blockade

Weight gain side effect from antipsychotics

5HT2C receptor antagonism

Mirtazapine's role in treatment

Acts as a 5HT2C receptor antagonist

Gastrointestinal side effects from antipsychotics

Caused by 5-HT3 receptor agonism.

Sexual dysfunction from SSRIs

5-HT2C receptor agonism

Define inverse agonist

An inverse agonist produces the opposite effect of a full agonist.

Buspirone mechanism of action

5HT1A partial agonist.

Role of lithium

An allosteric modulator and non-competitive antagonist.

Define GABA receptor

A ligand-gated ion channel at the post-synaptic nerve terminal.

Function of NMDA receptor

An excitatory neurotransmitter receptor that activates a ligand-gated ion channel.

Role of orexin

A neuropeptide that regulates sleep-wake cycles and autonomic brain functions.

Function of the hippocampus

Responsible for memory.

Role of the amygdala

Involved in emotions and emotional behavior.

What is the function of the anterior cingulate cortex?

Detection of errors, task anticipation, and emotion regulation.

Clozapine mechanism

Serotonin dopamine agonist with rapid dissociation from D2.

Effects of subcortical leukoencephalopathy

Associated with late-life depression.

Tardive dyskinesia movement characteristics

Choreiform movements affecting oro-buccolingual, truncal, and appendicular areas.

What is paranoid spiral in therapy?

Therapist feels persecuted by the patient, leading to overt and covert attacks.

Define restless leg syndrome treatment options

Dopaminergic agents and anticonvulsants like Gabapentin and Clonazepam.

Characteristics of Broca’s aphasia

Inability to speak fluently, with impaired repetition but still able to comprehend.

What is anosognosia?

Lack of awareness of one's own disease.