A type of channel (gap junction) where electrical and inorganic ions are exchanged.
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6 connexins =1…?
Connexon
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What are hemidesmosomes?
multiprotein complexes that facilitate the stable adhesion of basal epithelial cells to the underlying basement membrane
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What is the difference between desmosomes and hemidesmosomes?
Desmosomes are junctions involved in intercellular adhesion of epithelial cells and hemidesmosomes are junctions involved in adhesion of epithelia to basement membranes
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what do selectins bind to?
Glycoproteins and Glycolipids
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What technique can be used to study cancer cell migration?
Wound healing experiment
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What are tight junctions formed from?
Claudins and occludins
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What are adherens junctions made from?
Desmosomes and cadherens
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What are focal adhesions?
Adhesion and Cell migration → specialized sites within the cell where clustered integrin receptors interact with the extracellular matrix on the outside of cells and with the actin cytoskeleton on the inside
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For what is the focal adhesion turnover important?
Cell Migration
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What type of molecule is especially present in the focal adhesion?
Integrins
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What are 4 components of the extracellular matrix (ECM)?
1\.Proteoglycans
2\.Collagen
3\.Glycoproteins
4\.Elastin
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What is GAG?
Glycosaminoglycans
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Is collagen hydrophobic or hydrophilic?
HYDROPHOBIC
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What is fibronectin used for?
As a track for the movement of cells by Focal adhesion binding
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Is elastin Hydrophobic or hydrophilic?
HYDROPHOBIC
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Microvesicles and exosomes released from cancer cells can be used for what?
Can be found in blood and urine and used for diagnosis of cancer
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What do metalloproteases (MMP) do?
They degrade the extracellular matrix to allow for migration
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What two phospholipids play an important role in cell polarity?