Cancer bio EXAM topic 5 and 6

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59 Terms

1
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What does EMT stand for?
Epithelial mesenchymal transition
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What are cadherins linked to?
Catenins
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What is a CAM?
Cell adhesion molecule
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what are the three types of selectins?
1\.P-selectin

2\.L-selectin

3\.E-selectin
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What does integrin bind to?
VCAM
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What are connexins?
A type of channel (gap junction) where electrical and inorganic ions are exchanged.
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6 connexins =1…?
Connexon
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What are hemidesmosomes?
multiprotein complexes that facilitate the stable adhesion of basal epithelial cells to the underlying basement membrane
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What is the difference between desmosomes and hemidesmosomes?
Desmosomes are junctions involved in intercellular adhesion of epithelial cells and hemidesmosomes are junctions involved in adhesion of epithelia to basement membranes
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what do selectins bind to?
Glycoproteins and Glycolipids
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What technique can be used to study cancer cell migration?
Wound healing experiment
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What are tight junctions formed from?
Claudins and occludins
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What are adherens junctions made from?
Desmosomes and cadherens
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What are focal adhesions?
Adhesion and Cell migration → specialized sites within the cell where clustered integrin receptors interact with the extracellular matrix on the outside of cells and with the actin cytoskeleton on the inside
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For what is the focal adhesion turnover important?
Cell Migration
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What type of molecule is especially present in the focal adhesion?
Integrins
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What are 4 components of the extracellular matrix (ECM)?
1\.Proteoglycans

2\.Collagen

3\.Glycoproteins

4\.Elastin
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What is GAG?
Glycosaminoglycans
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Is collagen hydrophobic or hydrophilic?
HYDROPHOBIC
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What is fibronectin used for?
As a track for the movement of cells by Focal adhesion binding
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Is elastin Hydrophobic or hydrophilic?
HYDROPHOBIC
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Microvesicles and exosomes released from cancer cells can be used for what?
Can be found in blood and urine and used for diagnosis of cancer
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What do metalloproteases (MMP) do?
They degrade the extracellular matrix to allow for migration
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What two phospholipids play an important role in cell polarity?
PIP2 and PIP3
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Vimentin is a …?
Mesenchymal intermediate filament
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What are the 5 steps of mesenchymal migration?
1\.Polarization

2\.Lamellipodium formation dendritic actin network (protrusion)

3\.Formation of new adhesions (attachment)

4\.Cell body contraction (traction)

5\.Rear retraction
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Do MET or EMT intravasate?
EMT
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Do MET or EMT extravasate?
MET
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At what phase of life is EMT normal?
During embryonic development
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What is apoptosis also known as?
Cell suicide or silent cell death
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what are the 3 phases of apoptosis?
Initiation→ decision→ execution
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What does a mutation in bcl2 lead to?
Cell cannot go through apoptosis
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Apoptosis happens due to the ……….. cascade
Caspase
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Initiator caspases activate ………?
Effector caspases
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What are the two types of apoptotic pathways?
Extrinsic and Intrinsic pathway
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What do Apoptotic signals bind to ?
DISC
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List 3 examples of drugs targetting apoptosis
1\.Bcl2 inhibitors

2\.IAP inhibitors

3\.Death receptor agonist
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What do IAPs bind to?
caspases
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What do IAPS do?
Inhibit caspases
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What is autophagy?
A survival pathway
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What is the principal mechanism of autophagy?
the isolation of intracellular material in autophagosomes and its degradation in autophagolysosomes
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What is the main molecule that regulates autophagy?
LC3
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What does BAX promote?
Apoptosis
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What is random autophagy?
The random sequestration of cytosolic components usually due to limiting nutrients in the environment
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What is selective autophagy?
Recognition of specific cargos like a damaged mitochondria
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What induces autophagy?
Stress factors
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True or False: Autophagy can be pro-tumour or anti-tumour
True
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Necrotopsis is activated when ……….. is blocked
Apoptosis
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What does TME stand for?
Tumour Microenvironment
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What can inhibit Necroptosis?
Necrostatin
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True or False: No inflammation occurs with necrosis
FALSE
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What is Pyroptosis?
Induction of inflammation
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What are the two pathways of pyroptosis?
1\.Canonical pathway

2\.Non-canonical pathway
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Which caspase is activated in pyroptosis?
Caspase 1
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In pyroptosis, does inflammasome formation occur before or after activation of caspase 1?
before
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In pyroptosis, what does GSDMD cleavage lead to?
Pore formation
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True or False: In cancer, there is a downregulation of caspase 1 and GSDMD
True
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What is entosis is also known as …..?
Cell canibalism
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Is the cell alive or dead during entosis?
Alive