B-Cell Development & Negative selection of B cells in the bone marrow

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5 Terms

1
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What is required at each developmental stage of B-cell development?

Recombination events to produce a functional B-cell receptor.

2
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What occurs at each stage of B-cell development to ensure proper formation?

Rearrangement of heavy and light chain loci and checkpoints to ensure productive rearrangements.

3
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What does positive selection in B-cell development require?

Productive rearrangement at an immunoglobulin light chain locus.

4
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After positive selection, what must the new B cells be tested for?

To determine if they are self-reactive.

5
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What are the three possible fates of self-reactive immature B cells?

1. Clonal deletion
2. Receptor editing
3. Anergy