Blood Bank Exam 2

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A

What antigens are on RBCs in blood group A?

B

What antibodies are in the plasma of blood group A?

A and O

What are the compatible RBC types for blood group A?

A and AB

What are the compatible FFP types for blood group A?

B

What antigens are on the RBCs in blood group B?

A

What antibodies are in the plasma of blood group B?

B and O

What are the compatible RBC types for blood group B?

B and AB

What are the compatible FFP types for blood group B?

A and B

What antigens are on the RBCs of blood group AB?

None

What antibodies are present in the plasma of blood group AB?

All

What are the compatible RBC types of blood group AB?

AB

What are the compatible FFP types of blood group AB?

None

What are the antigens on the RBCs in blood group O?

A and B

What are the antibodies in the plasma of blood group O?

O

What are the compatible RBC types of blood group O?

All

What are the compatible FFP types of blood group O?

Landsteiner

Who discovered the ABO blood group?

Codominant

What inheritance type does the ABO system have?

Acetylgalactosamine

What is the A immunodominant sugar?

Galactose

What is the B immunodominant sugar?

Fucose

What is the O immunodominant sugar?

None

What is the O_h immunodominant sugar?

O_neg (Bombay)

What ABO/Rh type does O_h appear as?

A₁ and A₂

What are the 2 main A subgroups?

1. 80%

2. 20%

What percent of the population is

1. A₁

2. A₂

Exposure and/or transfusion

How are ABO antibodies developed?

IgM

What immunoglobulin class are the ABO antibodies classified as?

Cold

What is the preferred temperature for the ABO antibodies?

Exposure and/or transfusion

How are ABO antibodies developed?

Dolichos biflorus

What is the anti-A₁ lectin made of?

Ulex europaeus

What is the anti-H lectin made of?

80%

What percent of people are secretors?

20%

What percent of people are none secretors?

1 and 2

What geneotype(s) are secretors?

1. Sese

2. SeSe

3. sese

B, H, and Se

If a person is BB, HH, Sese what antigens are in their saliva?

Old age/less antibodies

What causes missing reverse reactions?

Bombay

What are causes of missing forward reactions?

Recent transfusion

What causes an acquired B pheotype?

O_neg

What is the universal RBC donor type?

AB_pos

What is the universal FFP donor type?

D Control Test

When typing what else needs done if the patient is AB_pos?

1. O

2. A₂

3. B

4. A₂B

5. A₁

6. A₁B

Rank ABO types form most to least H antigen: A₁, A₂, A₁B, A2B, B, O

• Rh1 = D

• Rh2 = C

• Rh3 = E

• Rh4 = c

• Rh5 = e

What is the Rosenfield notation for the following 5 main Rh antigens

• Rh1

• Rh2

• Rh3

• Rh4

• Rh5

• R₀ = Dce

• R₁ = DCe

• R₂ = DcE

• R_Z = DCE

• r = ce

• r’ = Ce

• r” = cE

• r^y =CE

What are the Rh antigens associated with the following Weiner genotype?

• R₀

• R₁

• R₂

• R_Z

• r

• r’

• r”

• r^y

85%

What percent of the population is D_pos?

15%

What percent of the population is D_neg?

Codominant

What kind of inheritance does the Rh system have?

Rh_null

What kind of phenotype do you transfuse an Rh_null person with?`

D-deletion

What kind of phenotype do you transfuse a D-deletion person with?

Partial, genetic, and postion

What are the 3 types of weak D?

Partial

Which of the weak D types can form anti-D?

Donors and mothers

What patients require a weak D test?

IAT

What type of test is the weak D test?

AB_pos and Weak D test

When does an Rh control need to be run?

Avoid HDFN

Why is it important to identify Rh_neg moms?

Phenotypically

How is LW related to Rh?

Fy^a and Fy^b

What are the two main antigens of the Duffy blood group?

IgG

What antibody class is the Duffy blood group?

Yes

Does the Duffy blood group show dosage?

AHG

What is the preferred reaction phase of the Duffy blood group?

No

Does the Duffy blood group bind complement?

Ficin

What can Duffy antigens be denatured with?

Resistant to Plasmodium vivax and P. knowlesi

What is special about the Fy^a and Fy^b cells?

K( kell) and k (cellano)

What are the 2 major antigens of the kell blood system?

k (cellano)

What is the most common phenotype in the Kell blood system?

IgG

What antibody class is the Kell blood system?

No

Does the Kell system bind complement?

No

Does the Kell system show dosage?

IAT

What is the preferred phase for the Kell system?

DTT (Sulfhydryl)

Kell system antigens can be denatured with what reagents?

No

Do enzymes have and effect on the Kell system?

Both are on Chromosome 7

How is K_x related to the Kell system?

McLeod

What phenotype arises from a person being K_xneg?

Jk^a, Jk^b, and Jk3

What are the 3 main antigens of the Kidd system?

IgG

What antibody class is the Kidd system?

Yes

Does the Kidd system show dosage?

AHG

What is the preferred reaction phase of the Kidd system?

Anti-Jk3

What antibody can Jk^a-Jk^b produce?

Titers can drop to undetectable

When are the Kidd antigens known as treacherous kids?

M+N and S+s

What are the antithetical antigens of the MNS system?

IgG

What is the antibody class of the MNS system?

Yes

Does the MNS system show dosage?

MN=RT Ss=IAT

What is the preferred reaction phase for the MNS system?

MN

Which MNS antigens are associated with glycophorin A?

Ss

Which MNS antigens are associated with glycophorin B?

S and s

U_neg blood cells are also negative for which MNS system antigens?

Anti-N

What antibody from the MNS system is associated with dialysis patients?

Absorbed onto RBCs

How are lewis system antigens formed?

No

Are lewis system antigens clinically significant?

IgM

What antibody class are lewis system antigens?

Le^a

The inheritance of the Le gene produces what?

When the Se gene is present on the D-galactase

When is the Le^a antigen converted to the Le^b antigen?

I

What Ii system antigen is associated with adults?

i

What Ii antigen is associated with newborns?

I

What Ii antigen is associated with Mycoplama pneumoniae?

Yes

Does the Ii system have cold autoantibodies?

i

Which of the Ii antigens has linear chains?

I

Which of the Ii antigens has branched chains?

Yes, in babies

Are the Ii antigens clinically significant?

Immediate Spin

What is the preferred reaction phase of the Ii system?