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Monosomy
This refers to the the loss of a single chromosome from an otherwise diploid genome
Nondisjunction
This is the process wherein paired homologs fail to disjoin during segregation
Translocation
A chromosomal segment that breaks off and attaches to another chromosome is what type of mutation?
Monosomy for any of the autosomes is usually tolerated in humans or other animals.
Which of the following is incorrect regarding monosomies
Down Syndrome and Patau syndrome
Intellectual disability
Patau syndrome
Cleft lip and palate
Patau syndrome
Cryptorchidism
Down Syndrome
epicanthic fold in each eye
Down Syndrome
Single palmar crease
Patau syndrome
Early lethality
DSR gene suppresses vascular endothelial growth factor (VEGF) → blocks the process of angiogenesis
Which of the following is incorrect regarding Down syndrome?
Meiosis is initiated in all the eggs @ fetal age → arrested in meiosis II
Which of the following is incorrect regarding hypothesis on incidence of down syndrome on increasing maternal age?
35
At what maternal age does the incidence of down syndrome increase?
47, 13+
Which of the following is the karyotype for Patau syndrome
Alloploidy
This refers to the the combination of chromosome sets from different species occurring as a consequence of hybridization
Autoploidy
This refers to the addition of one or more extra sets of chromosomes, identical to the normal haploid complement of the same species
Translocation
Chronic myelogenous leukemia (CML) is caused when a segment of chromosome 9 and a segment of chromosome 22 both break off and switch places. What type of mutation is this?
Intron
In organisms with large genomes, inversions are more likely to be tolerated if the breakpoints occur in:
They can produce new alleles of existing genes.
Which of the following statements is true about mutations?
Autoploidy
This arises as a result of a failure of all chromosomes to segregate during meiotic divisions which was then fertilized by a haploid gamete and produced a zygote with three sets of chromosomes is produced
Inversion
Does not involve a loss of genetic information but simply rearranges the linear gene sequence
Deletion
Missing piece when a chromosome breaks in one or more places and a portion of it is lost
Translocation
involves the exchange of segments between two nonhomologous chromosomes
Translocation
Leads to semisterility
Duplication
When any part of the genetic material, a single locus or a large piece of a chromosome, is present more than once in the genome
Deletion
Cri Du Chat syndrome
Duplication
Gene redundancy in rRNA
Duplication
Bar eye phenotype Drosophila
Inversion
is a type of chromosomal aberration in which a segment of a chromosome is turned around 180 degrees within a chromosome.
Translocation
Familial Down Syndrome
Down Syndrome
Typical flat face and round head
Patau syndrome
Double ureter
Down Syndrome
epicanthic fold in each eye
Chromosome 2
In Drosophila, monosomy for the larger chromosomes such as___ is apparently lethal because such flies have never been recovered
Chr 5
Cri du Chat syndrome results from a mutation involving the small terminal portion of whay chromosome number?
Haploinsufficiency
When a single copy of a recessive gene due to monosomy may be insufficient to provide life sustaining function for the organism, this is referred to as
47, 18+
Which of the following is the karyotype for Edwards syndrome
Trisomy
It is said that this chromosomal variation produces somewhat more viable individuals in both animal and plant species
true
True/ False:
Inversion suppresses the recovery of crossover products when chromosome exchange occurs within the inverted region
Incest
It is now known that mutations can arise from the following causes except?
Mutation
The ultimate source of new genetic variation in a species is:
Inversion
Offspring bearing crossover gametes are inviable and not recovered
Inversion
Same principle used in balancer chromosomes
Note
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