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What is the role of the proteasome in MHC class I peptide loading?
The proteasome cleaves intracellular proteins into small peptides of varying lengths.
How do cytokines influence the proteasome during an inflammatory response?
Cytokines can induce the formation of the immunoproteasome, which enhances MHC class I presentation.
What is the function of the 11S subunit in the immunoproteasome?
The 11S subunit aids in processing MHC class I molecules.
What is the role of β subunits in the immunoproteasome?
β subunits generate peptides that are 8 to 10 amino acids long, which are optimal for MHC class I binding.
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