Spironolactone (Aldactone) – Potassium-Sparing Diuretic
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Last updated 1:26 AM on 2/24/26
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5 Terms
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Mechanism of action
Blocks aldosterone, causing sodium/water loss while retaining potassium
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Primary therapeutic use
Heart failure
Hypertension
Hyperaldosteronism
PCOS (off-label)
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Major / deadly side effects
Hyperkalemia (can cause dysrhythmias)
Gynecomastia
Menstrual changes
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Critical teaching points
NO potassium supplements or salt substitutes
Monitor K⁺ closely
Wear gloves if handling (pregnancy risk)
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Easy memory
“Saves potassium” but can save TOO much
