Immunology Cytokines

IL 1 produced by what

macrophages

IL 1 principle target cell

body wide for inflammation

IL 2 produced by what

Th cells

primarily Th1

IL2 principle target cell

Th cells for proliferation and differentiation of both Th and CTLs

IL4 produced by

Th2 cells

IL4 principle target cell

B cells: isotope switching to IgG in GI (outside of lymphatic tissue, peyers patches)

T cells: Th2 differentiation, proliferation

IL5 produced by

Th2 cells

IL5 principle target cell

B cells for isotope switching to IgA in GI (in lymphatic tissue and peyers patches)

IL6 produced by

classic APDCs

IL6 principle target cell

T cells for Th17 differentiation in combination with TGF-beta

IL12 produced by

classic APDC

IL12 principle target cell

T cells for Th1 differentiation

IL13 produced by

Th2 cells

IL13 principle target cell

investing for goblet cells that stimulate mucus secretion in GI

IL17 produced by

Th17 cells

IL17 principle target cell

neutrophils that are recruited

IL21 produced by

Tfh cells

IL21 principle target cell

B cells for T cell dependent B cells activation allowing for memory B cells

IL22 produced by

Th17 cells

IL22 principle target cell

T cells for differentiation and expansion of Th17 cells

IL23 produced by

Th17

IL23 principle target cell

nTreg/iTreg to restrain Foxp3 to allow up regulation of B7 on APCs to facilitate T ells

IFN-y produced from

Th1, CTL, NK, ILCs, dying body cells, virus infected cells

IFN-y principle target cell

macrophages: goes from resting to primed/activated

B cells: isotope switching to opsonizing and complement fixing IgG

T cells: Th1 differentiation

APDC: activation and upregulation of MHC II

CTLs: up regulation of MHC I, antiviral effects

TNF/TNFa produces from

macrophages, NK cells, Th1, neutrophils, dying body cells

TNF/TNFa principle target cell

body wide: inflammation and pain

macrophages: goes from resting to primed/activated

APDC: activation and up regulation of MHC and B7

neutrophils: activation

macrophage secretion of TNFa can be modulated via

cholinergic anti-inflammatory pathway by activation of the vagus nerve

IL10 produced from

iTreg/pTreg

IL10 principle target cell

T cells: inhibition of costimulatory signal CD28 causing the T cells to be anergized

Macrophages: represses inflammatory cytokines

classic APDC: repressed inflammatory cytokine IL6

TGFb produced from

iTreg/pTreg

TGFb principle target cell

classic APDC: inhibition of proliferation and formation of Th1 and Th2 of their cytokines

itreg: promotes survival, development, function

Th: in combo with IL6 differentiates into Th17

CTLs: inhibtion of proliferation and reactivation reduction of CTL killing ability

B cells: IgA production

Macrophages: inhibition of activation

IFN a and b produced from

viral infected cells

IFN a and b principle target cell

uninfected cells for antiviral responses (innate immune)

Th1 defining cytokines

TNF

IL2

IFN-y

Th1 principle target cell

macrophages

Th1 immune reactions

NK cells

CTLs

Macrophage activation

Th1 host defense

intracellular pathogens (bacteria in tissues)

Th1 Role in disease

autoimmunity and chronic inflammation

Th2 defining cytokines

IL4

IL5

IL13

Th2 principle target cell

Eosinophils

Th2 major immune reactions

eosinophil and mast cell activation

alternative macrophage activation

IgA and IgE

Th2 host defense

Parasites, helminths, bacteria in the GI

Th2 role in defense

allergy

Th17 defining cytokines

IL17

IL22/21

IL23

Th17 principle target cell

Neutrophils

Th17 major immune reaction

neutrophil recruitment and activation

Th17 host defense

extracellular bacteria and fungi

bacteria in mucosa

Th17 role in disease

autoimmunity and inflammation

Tfh defining cytokines

IL21 and IFN-y/IL4

Tfh principle target cell

B cells

Tfh major immune reaction

antibody production

Tfh host defense

Extraceulluar pathogens

Tfh role in disease

Autoimmunity (autoantibodies)