Paracetamol

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12 Terms

1
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Phenacetin

Renal papillary necrosis

2
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Inhibit COX with no inflammatory effect

MOA of paracetamol

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500mg every 4 hours

Therapeutic dose of paracetamol in adults

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10-25mg/kg/dose

Paracetamol therapeutic dose in children

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4g/day

Toxic dose of paracetamol

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15g/day

Lethal dose of paracetamol

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Sulfation

Good metabolite of paracetamol

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Glucuronidation

Nontoxic metabolite of paracetamol

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Oxidation

Paracetamol pathway, toxic metabolire

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NAPQI (N-acetylparabenzoquinomeimine)

Paracetamol is metabolized by CYP2E1.

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Glutathione

Turns NAPQI to nontoxic

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N-acetylcysteine

Target NAPQI to turn it into nontoxic

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