Order of reactivity (Carboxylic acid derivatives)

1. Acid halides (acid chloride)

2. Anhydride

3. Ester

4. Amide

5. Carboxylic acids

Acid halides are more reactive than anhydrides, esters, amides and carboxylic acid. Anhydrides are more reactive than esters, amides and carboxylic acids. Esters are more reactive than amides and carboxylic acids. Amides are more reactive than carboxylic acids

H

E

H