GI+Meds;Serotonin Antagonists: ondansetron
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5 Terms
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mechanism of action; ondansetron
Blocks 5-HT3 serotonin receptors located in the chemoreceptor trigger zone of the brain & antagonizing of the vagal nerve that innervates the stomach & small intestines.
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therapeutic use
Prevents emesis r/t chemotherapy, radiation therapy, & post-op recovery
Given PO, IM, or IV
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Complications
Headache, diarrhea, dizziness
Prolonged QT interval can lead to serious dysrhythmias (torsades de pointes)
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Contraindications/precautions
Safety not established with pregnancy or lactation
Clients who have long
QT syndrome
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interactions
CNS depressants
Antihypertensives meds
Anticholinergic meds
Note 
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