(4)Transgenic Animals Notes

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10 Terms

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Transgene

Introduced DNA.

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Transgenesis

The process of introducing foreign DNA into an organism.

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Pharming

Obtaining drugs from transgenic animal milk.

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Embryonic Stem Cell (ES Cell)

ES cells from blastocysts that can differentiate into any cell type and can be genetically engineered to create transgenic animals.

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Gene Knockdown

Introducing shRNA (short hairpin RNA) to target mRNA, leading to its degradation and reduced gene expression.

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Conditional Gene Knockdown

shRNA expression is regulated by an inducible promoter, allowing knockdown only under specific conditions.

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Gene Knockout

Involves inserting a selectable marker gene within a functional gene to disrupt its function.

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Gene Conditional Knockout

LoxP sites flank the target gene; Cre recombinase excises the gene, inactivating it.

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Tet-On System

Requires Dox for transgene transcription via a mutated tet repressor.

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Tet-Off System

Involves a hybrid protein (tTA) that