Pharmacology Flashcards Quiz 1 (Day 4)

14 items, 3 rows at a time

43) What is a dosing regimen? 

Route, amount, and frequency the drug is given

44) What influences the onset and duration of drug action? 

The dosing regimen

45) What is the onset of a drug? 

The amount of time it takes a drug to begin working.

46) What routes have the fastest and slowest onset? 

IV drugs are fastest onset, oral drugs are slowest

47) What is the duration of a drug? 

The length of time for which a drug is therapeutic.

48) What does the duration of a drug usually correspond to? 

The half-life of the drug

49) When would the duration of a drug not correspond to its half-life? 

When the drug binds irreversibly to its receptor

50) What is the duration of a drug dependent upon? 

The metabolism and excretion of the drug.

51) Will increasing the rate of IV infusion decrease the time needed to reach steady state?

No; it always takes 4-5 half-lives of continuous IV infusion to reach steady state.

52) Will increasing the rate of IV infusion increase the plasma drug concentration at steady state?

Yes (see page 3 in book if you bought it). Instead of administering x-mg per hour, increasing infusion to 2x-mg will result in drug concentration being doubled at steady state (when the graph levels off)

53) What is the peak and trough of a drug?

When a drug is administered intermittently, there will be peaks (high points of fluctuation) and troughs (low points of fluctuation) See page 3 in book

54) Are toxic effects most likely to occur during peaks or troughs? 

Peaks

55) Is lack of drug effects more likely to occur during peaks or troughs? 

Troughs

56) Is post-operative pain more likely to return just before a second dose of morphine or midway between the first and second dose?

Just before the second dose