Chapter 18 - Formation of Acetyl CoA

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11 Terms

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What are the three enzymes and five coenzymes involved in the conversion of pyruvate to acetyl
CoA?

enzymes: pyruvate dehydrogenase, dihydrolipoyl transacetylase, dihydrolipoyl dehydrogenase

coenzymes: FAD, NAD+, Coenzyme A, lipoic acid, TPP

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E1

pyruvate dehydrogenase

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E2

Dihydrolipoyl transacetylase

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E3

Dihydrolipoyl dehydrogenase

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E1 prosthetic group

TPP

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E2 prosthetic group

Lipoamide

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E3 prosthetic group

FAD

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E1 reaction

decarboxylation of pyruvate

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E2 reaction

Oxidation of acetyl CoA

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E3 reaction

Acyl transfer to CoA

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