ACLE

What is Acute Cutaneous Lupus Erythematosus (ACLE)?

ACLE is a subtype of cutaneous lupus erythematosus characterized by transient lesions, often appearing after sun exposure.

What is the typical presentation of ACLE?

Malar erythema, commonly known as the 'butterfly rash', is a typical presentation of ACLE.

What is the association between ACLE and systemic lupus erythematosus (SLE)?

ACLE is often associated with active SLE and can present with lesions that may resolve without scarring.

What environmental factor is significantly involved in the pathogenesis of ACLE?

Ultraviolet radiation (UVR) plays a significant role in the pathogenesis of ACLE.

What cytokines are induced by UVR in ACLE?

Proinflammatory cytokines such as tumor necrosis factor (TNF), interleukin (IL)-1, and interferon-γ (IFN-γ) are induced by UVR.

How long can ACLE lesions last?

Lesions can last from a few hours to several weeks.

What is Rowell Syndrome in relation to ACLE?

Rowell Syndrome describes erythema multiforme-like lesions that may occur in lupus patients.

What is the most valuable diagnostic test for ACLE?

Skin biopsy for H&E staining is the most valuable diagnostic test for ACLE.

What are the key lab tests to evaluate for systemic disease in ACLE?

Key lab tests include ANA/ENA, Anti-dsDNA, urinalysis, FBE, UE, LFT, ESR, CRP, and complement levels.

What is a major treatment modality for ACLE?

Topical corticosteroids are considered a mainstay of therapy for ACLE.

What is the relationship of ACLE lesions to sun exposure?

ACLE lesions often appear after sun exposure due to the effects of ultraviolet radiation.

Which demographic is more affected by systemic lupus erythematosus (SLE)?

SLE is more common in women, especially during childbearing years, and particularly in African-American women.

What characterizes the histopathology of ACLE?

Histopathology of ACLE shows mild interface dermatitis with vacuolization of basal keratinocytes.