Haemoglobin and myoglobin
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17 Terms
how many coordination sites does iron have
6
what is the organic component of haem that has 4 coordination sites
protoporphyrin 9
what is in the 5th coordination site
proximal histidine F8
how many subunits does myoglobin have
1
how many alpha helices in a myoglobin subunit
8
what are the subunits of haemoglobin
alpha2beta2
In fetal haemoglobin, what subunit replaces the beta subunit
gamma
In the fetal haemglobin subunit, which AA residue is replaced an what with
His143, Ser143
what are 4 allosteric inhibitors
H+, CO2, Cl-, BPG
what does BPG do to oxygen affinity
decreases
what are the two structural states of haemoglobin
T,R
what state is deoxyhaemoglobin in
T
what state is oxyhaemoglobin in
R
between which helices is the haem binding pocket
E and F
which state does BPG stabilize
T
What is the amino acid mutation in sickle cell anaemia
E6V
what is the type of thalassemia where there are 4 beta chains
alpha-thalassemia
Note 
Flashcards (53)