LESSON 1 DEF OF TERMS AND HISTORY OF IMMUNOSERO

List of Scientists and Their Contribution to Immunology and Serology

Smallpox vaccination

1798 Jenner

Phagocytosis

1862 Haeckel

Live, attenuated chicken cholera and anthrax vaccines

1880-1881 Pasteur

Cellular theory of immunity through phagocytosis

1883-1905 Metchnikoff

Therapeutic vaccination; First report of live “attenuated” vaccine

for rabies

1885 Pasteur

Humoral theory of immunity proposed

1890 Von Behring, Kitasata

Demonstration of cutaneous hypersensitivity

1891 Koch

Antibody formation theory

1900 Ehrlich

Immediate-hypersensitivity anaphylaxis

1902 Portier, Richet

reaction of intermediate hypersensitivity

1903 Arthus

Hypothesis of antigen-antibody binding

1938 Marrack

Hypothesis of allograft rejection

1944

Development of polio vaccine

1949 Salk, Sabin

Vaccine against yellow fever

1951 Reed

Graft-versus-host reaction

1953

Clonal selection theory

1957 Burnet

Interferon

1957

*Antihistamines

1957 Daniel Bovet

HLA’s

1958-1962

T cell and B cell cooperation in immune response

1964-1968

Identification of antibody molecule

1972

*Chemical structure of antibodies

1972 Rodney R. Porter

Gerald M. Edelman

First monoclonal antibodies

1975 Kohler

*Development of radioimmunoassay

1977 Rosalyn R. Yalow

*Major histocompatibility complex

1980

George Snell

Jean Dausset

Baruj Benacerraf

*Immune regulatory theories

1984 Niels K. Jerne

Identification of genes for T cell receptor

1985-1987

Monoclonal hepatitis B vaccine

1986

Th1 versus Th2 model of T helper cell function

1986 Mosmann

*Gene rearrangement in antibody production

1987 Susumu Tonegawa

Identification of toll-like receptors

1996-1998

FOXP3, the gene directing regulatory T cell development

2001

Development of human papillomavirus vaccine

2005 Frazer