Thinking Like a Malignant Hematologist

communicating complicated concepts with patients- understanding WBC

understanding elevated lymphocytes (ALC)

making the CLL diagnosis- flow cytometry testing

understanding CLL- patient journey, variable treatment course

how CLL moves through the body- blood, lymph nodes, spleen

staging the disease- Rai staging system

understanding cytopenias (low blood counts)- bone marrow as a garden

what happens when weeds (CLL cells) take over?

when do we treat CLL

goals of CLL/SLL treatment

prognostic testing in CLL

prognostic factors

tp53 aberrations- mutation testing in CLL

CLL- tp53

clinical cancer genomics

“first” generation Sanger sequencing

next generation sequencing (NGS) workflow

key NGS concept- coverage

_____ limits depth of sequencing

-size of the capture

CLL cells have a different DNA “recipe book”

modern goals of therapy for patients with CLL

fixed-duration ven-obin: 6 year follow-up of CLL14

CLL14: PFS by genetic subgroup

PFS in pts with mutated and unmutated IGHV genes

consistent outcomes regardless of

-Del(17p) status

approach to anemia

interpretation of iron studies

choosing the right treatment strategy

BTIK inhibitors

how long do BTK inhibitors work?

venetoclax