OChem Sn vs E Predictions

The Reaction is . . .

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Hot

Elimination (E)

Cold

Substitution (Sn)

The Elimination reaction has 1 degree Carbon

E2

The Elimination reaction has either 2 or 3 degree Carbon

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Elimination reaction has a strong base or Weak L.G.

E2

Elimination reaction lacks a strong base or has a strong L.G.

E1

If the reaction is capable of rearranging it. . .

If the reaction is capable of rearranging it will and it is E1; if it doesn’t then it cannot rearrange and go through the tree again.

Substitution Reaction has 3 degree carbon

Sn 1

Substitution reaction has 1 degree carbon

Sn2

Substitution reaction has 2 degree carbon

Either, continue down the tree

Substitution reaction has a Weak nucleophile and a strong L.G.

Sn1

Substitution reaction has a strong nucleophile and a weak L.G.

Sn2