CHAT GTP Questions For Immunology

Which of the following is NOT a nonspecific mucosal defense mechanism?

Secretion of IgA antibodies

What is the primary function of M cells in the gut?

Transporting antigens to the gut-associated lymphoid tissue (GALT)

Secretory IgA functions primarily by:

Binding to microbes to prevent their attachment to epithelial cells

Which of the following cytokines is most associated with inducing IgA class switching?

TGF-beta

The gastrointestinal immune system relies on __________ to transport antigens to gut-associated lymphoid tissue

M cells

The main function of Peyer's patches is:

To generate immune responses against gut antigens

Dendritic cells in the gut mucosa contribute to immune tolerance by promoting the development of:

Regulatory T cells (Tregs)

Toll-like receptors (TLRs) in the gut are located primarily on the:

Basolateral membrane and cytoplasm

One function of gut microbiota is:

To outcompete pathogenic bacteria

What is the role of defensins in mucosal immunity?

They disrupt microbial membranes, leading to cell lysis

Type I hypersensitivity is mediated by which antibody?

IgE

Which immune cell type is most responsible for the symptoms of anaphylaxis?

Mast cells

In type II hypersensitivity, tissue damage occurs due to:

Antibody-mediated cytotoxicity

Myasthenia gravis is an example of which type of hypersensitivity reaction?

Type II

Rheumatoid arthritis is primarily associated with:

Type IV hypersensitivity

The formation of immune complexes is characteristic of which hypersensitivity reaction?

Type III

Which hypersensitivity reaction involves T-cell mediated responses rather than antibodies?

Type IV

Which of the following is an example of a delayed-type hypersensitivity reaction?

Tuberculosis skin test reaction

3 multiple choice options

What is the primary cytokine responsible for eosinophil activation in hypersensitivity reactions?

IL-5

3 multiple choice options

What is the best immediate treatment for anaphylaxis?

Epinephrine

3 multiple choice options

Which type of graft rejection occurs within minutes to hours due to preformed antibodies?

Hyperacute rejection

3 multiple choice options

Direct allorecognition involves which of the following?

Recipient T cells recognizing donor MHC on donor APCs

3 multiple choice options

What is the main immune mechanism responsible for acute transplant rejection?

T-cell mediated cytotoxicity

2 multiple choice options

Which immunosuppressive drug inhibits IL-2 production, reducing T cell activation?

Cyclosporine

3 multiple choice options

Which type of transplant rejection develops over months to years and involves fibrosis?

Chronic rejection

2 multiple choice options

Graft-versus-host disease (GVHD) primarily occurs in which type of transplant?

Bone marrow transplant

3 multiple choice options

Which immune component plays a central role in chronic transplant rejection?

Fibroblast proliferation and vessel occlusion

3 multiple choice options

Which test is performed before transplantation to assess donor-recipient compatibility?

Crossmatch test

3 multiple choice options

Which type of rejection involves recipient APCs processing donor antigens and presenting them to recipient T cells?

indirect allorecognition

What is the primary goal of immunosuppressive therapy in transplantation?

Prevent recipient immune system from attacking the graft