Protein Structures

1° function

amino acid sequence determines function of protein

2° function

H-bonds in alpha helices and beta pleated sheets give stability and shape to the protein

3° function

r-groups determine binding regions

4° function

important for proteins that need multiple subunits to work together

2° affect

the change in the amino acid sequence can disrupt the hydrogen bonds that stabilize alpha helices and beta pleated sheets. This can destabilize the secondary structure.

3° affect

Changes in the primary structure can change the way the protein folds. The interactions can be affected, leading to incorrect folding and destabilization of the protein.

4° affect

If the protein needs multiple subunits, the changes in the tertiary structures of each individual subunit can change how they all interact with each other. This can disrupt the formation of the protein.