4: IMMUNITY: phagocytosisand

Pinocytosis?

A mechanism in which cells absorb liquid from outside

Phagocytosis?

digestion of particles

Name 4 types of phagocytes

neutrophils, monocytes, macrophages, dendritic cells

Describe process of phagocytosis

1. Target adheres to the phagocyte surface

2. Phagocyte engulfs it into a phagosome

3. Phagosome fuses with lysosome to digest the microbe

4. Indigestible material is expelled by exocytosis

When do phagocytes express receptors on their cell surface?

For carbs

glycans

LPS

antibodies

Describe the process of phagocytosis

)

1. Neutrophils detect fungi/bacteria via receptors.

2. Neutrophils bind and engulf the microbes.

3. Neutrophils destroy microbes using toxic granules.

4. Macrophages produce inflammatory cytokines after receptor signaling.

Where are neutrophils stored?

in bone marrow

Opsonisation?

A process in which components of the immune system in serum make target more attractive for phagocytes

Using- antibodies/complement components

Antibodies?

Y shaped protein molecules produced by B CELLS that can neutralise pathogens