T-cell receptor signaling molecules

What is necessary for T-cell clonal selection?

The T-cell receptor/MHC-peptide/coreceptor complex is necessary for clonal selection, along with co-stimulation.

What signaling molecules link receptor–peptide interaction to activation?

Signaling molecules such as the CD3 complex, CD28, and CD45 are required to link receptor–peptide interaction to signaling events that activate the cell.

What is the result of T-cell signaling molecule activation?

These signaling molecules activate gene transcription that produces cytokines required for activation and differentiation.

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