Pancreatic cancer
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Last updated 4:47 PM on 1/26/23
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7 Terms
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associations
increasing age, smoking, diabetes, chronic pancreatitis, hereditary non polyposis colorectal carcinoma, multiple endocrine neoplasia, BRCA2, KRAS
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features
classically painless jaundice, pale stools, dark urine, pruritus, weight loss, anorexia, epigastric pain as well, atypical back pain, lots of endocrine and exocrine function, Trousseau sign
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investigations
ultrasound, high res ct, double duct sign - dilation of common bile and pancreatic duct, CA19-9, biopsy
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management
Whipple’s resection for resectable lesions at head of pancreas, chemo, ERCP with stunting (palliative), poor prognosis
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referral
over 40 with jaundice for 2 week wait, over 60 with weight loss + one other symptom for CT abdomen
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Courvoisier’s law
palpable gall bladder with jaundice is usually cholangiocarcinoma or pancreatic cancer
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trousseau’s sign of malignancy
migratory thrombophlebitis
Note 
Flashcards (40)