Lecture 11 (MG)

What is the pathophysiology of MG?

• ACh Receptors Blocked By Antibodies At Synapses

  • NMSK Signals Can’t Travel Normally

What is the age and gender prevalence of Myasthenia Gravis?

• Roughly: 3:2 Female:Male

• Most Often In:

  • “Younger” Women → 28 yrs

  • “Older” Men → 42 yrs

What is the race prevalence of Myasthenia Gravis?

• Asians > Other Races

What are the typical s/sx of MG?

• Diplopia (40%)

• Ptosis (25%)

• Dysarthria (16%)

• LE Weakness (13%)

• Dysphagia (10%)

• UE Weakness (7%)

What are the tests to identify MG?

• What are we looking for in each?

• Endrophonium Injection

  • For: Temporary Strength

• Chest CT / MRI

  • For: Thymus Gland Tumor

• Pulmonary Function

  • For: Respiratory Failure

How is prognosis of MG?

• Good If Treated Properly

  • S/Sx: Peak In 1st 1-3 Years

  • Life Expectancy: Often Normal

What is conventional MG tx?

• ACh Drugs

• Thymectomy

• Plasmapheresis

• IVIG

• Creatine (More Research Needed)

What does the MG Scale assess?

• Strength (13 Items)

• Fatigue (10 Items)

• ADLs (6 Items)

How is the MG-ADL scored?

• 0-3 Points Each, 8 Items, 24 Points Total

  • Higher Number = More Disability

What does the MG-ADL assess?

• Talking

• Chewing

• Swallowing

• Breathing

• Self-Grooming

• Sit To Stand

• Double Vision

• Eyelid Droop