HIV med notable ADRs

Which adverse effects are TAFs less associated with than TDFs?

Renal and bone mineral density changes

Which adverse effects are TAFs more associated with than TDFs?

Weight gain and dyslipidemia

What is the most clinically significant ADR associated with abacavir?

Life-threatening hypersensitivity reaction

What must be tested for prior to prescribing abacavir? Why?

Presence of HLA-B*5701 allele; significantly increases chance of having life-threatening hypersensitivity reaction to abacavir

Depression is associated with which drugs in what class?

Rilpivirine and doravirine, both NNRTIs

Insomnia is associated with which drugs in what two classes?

Rilpivirine and doravirine, both NNRTIs; and INSTIs

Dyslipidemia and increased triglycerides are associated with what drug class?

Protease inhibitors

Crystalluria is associated with which drug in what class?

Atazanavir, a protease inhibitor

Increased CKD risk is associated with which drug in what class?

Atazanavir, a protease inhibitor

QTc prolongation is associated with which drug in what class?

Atazanavir, a protease inhibitor

Increased CVD events is associated with which drug in what class?

Darunavir, a protease inhibitor

Significant weight gain is associated most strongly with which drug class?

Integrase inhibitors (return-to-health phenomenon?)

Which drug class is most associated with rash?

Protease inhibitors