Lec 29- Solid Tumors I

ALK rearrangement inhibitors

Alectinib

Brigatinib

Crizotinib*

Ceritinib

Ensartinib

Lorlatinib

All Big Cats Cry Eating Lasagna
All big cats can eat lasagna

MET exon skipping mutation inhibitors:

Classy Cats Tapdance

Capmatinib

Crizotinib*

Tepotinib

RET rearrangement inhibitors:

Sipping Piñas in Cabo

Selpercatinib

Pralsetinib

Cabozantinib

What are the class toxicities of the ALK re-arrangement inhibitors?

• Bradycardia

• Pulm toxicity

• Hepatotoxicity and photosensitivity (except Lorlatinib)

Which (if any) of the ALK rearrangement inhibitors ARE NOT responsible for or affected by CYP3A4 drug interactions?

Alectinib? (minor substrate)

Which of the ALK rearrangement inhibitors may prolong the QTc interval?

Ceritinib and Crizotinib

Which of the ALK rearrangement inhibitors is most likely to cause changes in mood, cognitive function, or even seizures?

Lorlatinib

Which of the ALK rearrangement inhibitors is most likely to cause hyperlipidemia?

Lorlatinib

Which of the ALK rearrangement inhibitors might be preferred in a patient with mild liver disease?

Lorlatinib

Which (if any) of the MET exon skipping mutation inhibitors ARE NOT responsible for or affected by CYP3A4 drug interactions?

Tepotinib? (minor substrate)

What are the class toxicities of the MET exon skipping mutation inhibitors?

• Hepatotoxicity

• Pulm toxicity

• Peripheral edema

• Cytopenia (lymphocytes and hemoglobin)

Which (if any) of the RET rearrangement inhibitors ARE NOT responsible for or affected by CYP3A4 drug interactions?

None? All major substrates

For which of the RET rearrangement inhibitors would you recommend regular liver function tests?

All (class effect)