PHM 321, Drug structures, identification, function recall

What structure is this?

Tetrodotoxin

What structure is this?

Saxitoxin, sodium channel blocker, leads to paralysis and respiratory depression

What structure is this?

Tyrosine

What structure is this?

L-DOPA

What structure is this?

Dopamine

What structure is this?

Norepinephrine

What structure is this?

Epinephrine

What structure is this?

VMA

Vanillylmandelic acid, major metabolite of NE in urine.

Function of alpha-1 receptors

Mixed (both inhibitory and excitatory)

VSM contraction - increase BP

GSM contraction - urine retention

ISM Relaxtion - decreased motility

Liver - Glycogenolysis and gluconeogenosis

Function of alpha-2 receptors

Inhibitory

Pancreas - Beta cell - decrease insulin secretion from pancreas

Platelet - Increased platelet aggregation - decreased BF

Nerve - Decrease NE release - inhibition of adenylyl cyclase

VSM - contraction - minor

Function of Beta-1 receptors (all Gs bound)

Excitatory

Heart - Chronotropy and Inotropy (increased heart rate and force of contraction)

Increased AV Node conduction

Renal Juxtaglomerular cells - increased renin - RAAS , increase BP through vasoconstriction and sodium retention

Function of Beta-2 receptors

SM Relaxation

Support alpha-1 in liver functions

Beta-3 functions

Brown adipose lipolysis in neonatal years

What structure is this?

General Amphetamine structure

Chemical name for pemoline

2-amino-5-phenyl-2-oxazolin-4-one

Chemical name for phendimetrazine

3,4-dimethyl-2-phenylmorpholine

Chemical name for methylphenidate

methyl-𝛼-phenyl-2-piperidine-acetate

What structure is this?

Methylone

What structure is this?

Cocaine

What structure is this?

Purine

What structure is this?

Xanthine

What structure is this?

Caffiene

What structure is this?

Theophylline

What structure is this?

Theobromine

What structure is this?

Nicotine

Where are M receptors found

CNS

• autonomic, PLC simulation, Aden. Cyc. inhibition, K+/Ca2+ channels regulation

Where are N receptors found

SNS + PNS, Post synaptic excitatory synapses

Function of M1 receptors

Late EPSP - increased chance of triggering action potential

CNS - arousal, attention, pain reduction (analgesia)

Function of M2 receptors

SA Node - slowed depolarization, slowed hyper polarization

AV Node - decreased conduction velocity

Atrium - decreased refractory period, decreased contractile force

Function of M3 receptors

SM - contraction

Function of M4 receptors

inhibits adenylyl cyclase

Modulate DA release, involved in motor control

Function of M5 receptors

Stimulate PLC for cerebral vasodilation

Nicotinic M vs N receptors

M - NM endplate depolarization (contraction), muscle contraction

N- Autonomic, post ganglionic neuron firing, catecholamine secretion

What is this structure?

Tryptophan

What is this structure?

5-hydroxytryptophan

What is this structure?

5-hydroxytriptamine or serotonin

What is this structure?

Ergotamine

What is this structure?

LSD, Lysergide

What is this structure?

Tryptamine

What is this structure?

Psilocin - 4-hydroxydimethyltryptamine

What structure is this?

PCP, 1-phenylcyclohexyl piperdine

What structure is this

Ketamine, 2-(ortho-chlorophenyl)-2-methylamino-cyclohexanone HCl