STEP 2: CLIP PRODUCTION

Where are MHC class II molecules transported after the ER?

MHC class II molecules are transported to the MHC compartment.

What happens to the invariant chain in the MHC compartment?

The protease cathepsin S cleaves the invariant chain but leaves a peptide called the class II-associated invariant chain peptide (CLIP) bound to the peptide-binding groove.

What happens to the endosome containing CLIP?

The endosome containing CLIP remains in an intracellular pool until it fuses with a phagolysosome.

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