STEP 2: CLIP PRODUCTION

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4 Terms

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Where are MHC class II molecules transported after the ER?

MHC class II molecules are transported to the MHC compartment.

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What happens to the invariant chain in the MHC compartment?

The protease cathepsin S cleaves the invariant chain but leaves a peptide called the class II-associated invariant chain peptide (CLIP) bound to the peptide-binding groove.

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What happens to the endosome containing CLIP?

The endosome containing CLIP remains in an intracellular pool until it fuses with a phagolysosome.

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