BB2 Other Blood Group Systems (Part 2)

These flashcards cover key concepts from Unit 2, Chapter 7 concerning various blood group systems, antigens, associated antibodies, and relevant clinical implications.

What is the primary antigen found in the I blood group system?

The primary antigen is the I antigen.

What is the significance of cold-reacting antibodies, such as auto anti-I?

They are clinically insignificant because they typically react in cold temperatures.

What are the three phenotypes of the P1PK blood group system?

P1, P2, and p (null) phenotypes.

What characterizes the M and N antigens in the MNS blood group system?

They are found on glycophorin A and consist of 131 amino acids.

What is one condition associated with anti-P1 antibodies?

Cold paroxysmal hemoglobinuria.

What is a crucial method for HLA serologic identification?

The lymphocytotoxicity test method.

What is the role of the Major Histocompatibility Complex (MHC)?

It is essential for recognition of self and non-self, coordinating cellular and humoral immunity.

What is the most common platelet antibody that may cause neonatal alloimmune thrombocytopenia (NAIT)?

The antibody directed against HPA-1a.

Which blood group system shows enhanced agglutination due to dosage effects?

The MNS blood group system.

What is a condition that may arise from HLA sensitization due to pregnancy?

Individuals may develop HLA antibodies, affecting graft survival.