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EXAM 4
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Cell membrane separate charges
ICF (-) relative to ECF (+)
membrane is polarized
RMP occurs only across cell membrane (thin layer)
Voltage measured between two points
reference electrode - ECF
Recording electrode - ICF
Potential energy measured in mV
Resting membrane potential = 70mV (neurons/muscle fibers)
Due to distribution of ions across membrane
ions important in polarization of neuron
most important
sodium
potassium
Proteins - largely trapped on inside of membrane
Chloride - near equilibrium
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