Blood Bank Lecture Exam III

MLS 4130

How many days before a pretransfusion specimen expires?

3 days

The American College of Surgeons recommends transfusion of RBCs, thawed plasma, and platelets in what ratio for a massive transfusion?

1:1:1

A patient's blood type is AB negative, but there are no AB negative RBC units available. What donor unit is the most appropriate selection?

A negative

HBsAg is what part of the hepatitis B virus?

Coat protein

Which of the following donors would be rejected for whole blood donation?

A male who had anal sex with a new male partner last week

Why are donors deferred for 3 months following receipt of blood products?

To permit adequate screening for transfusion-acquired viral infections

In an individual infected with hepatitis B virus, which of the following is detected first?

HBsAg

Which of the following donors would not be deferred?

Donor whose husband is a hemophiliac and received cryoprecipitate 10 years ago

Donors who have initially tested positive for HTLV I/II, but had a negative EIA when testing a second time are considered?

Eligible for donation

Which of the following would be cause for deferral for a male donor?

Hematocrit of 37%

What is the causative agent of Chagas disease?

Trypanosoma cruzi

Which of the following does not require a serological test for donor units?

Hepatitis A

Which of the following would be cause for permanent deferral?

Received a non-autologous dura mater graft 13 months ago

All of the following must be kept for 10 years, except:

Request for blood or blood component

Which of the following diseases can be transmitted through blood transfusion and is characterized by sponge-like lesions of the brain?

Creutzfeldt-Jakob disease

Which of the following tests is not required as a part of donor-processing procedure for allogenic donation?

Anti-CMV

According to the Centers for Disease Control (CDC), an HIV-positive person is considered to have AIDS according to what criterion?

Fewer than 200 CD4+ T cells per µL

Each unit of cryoprecipitate prepared from whole blood should contain a minimum of how many units of AHF activity?

80 IU

Random-donor platelets that have been leukoreduced must contain less than how many leukocytes?

8.3×10^5

Once cryoprecipitate has been thawed, what temperature should it be stored at until issued for transfusion?

22–24C

Which of the following component is correctly matched with its shelf life?

Deglycerolized RBCs: 24 hours

Once thawed, FFP must be transfused within how many hours unless relabeled as thawed plasma?

24

Cryoprecipitate pooled in an open system must be transfused within how many hours?

4

How does irradiation affect the shelf life of red blood cells?

The expiration date is 28 days after original expiration date OR irradiation date (whichever is sooner).

A unit of blood was returned to the blood bank before it was spiked. Apparently the patient’s IV failed. The unit of blood was outside the blood bank for 35 minutes. Which of the statements below is most accurate?

The units must be transfused within 4 hours or discarded by the end of that time period.

What is the major biochemical consideration in platelet storage?

pH regulation

A woman received a transfusion of packed RBCs while delivering her baby. Four months later she wanted to donate a unit of blood back to the American Red Cross. If the woman meets all other criteria for donation, is she allowed to donate at this time?

Yes

What is the minimum hemoglobin for an allogenic donor?

12.5

Cryoprecipitate is indicated for all but which of the following?

Hemophilia B

A patient has a baseline platelet count of 30,000/µL. Upon receiving a platelet pool of 4 random platelets, what would you expect the post-transfusion platelet count to be?

50,000/µL

Which of the following products does not require ABO compatibility?

Cryoprecipitate

What is the advantage of performing a type and screen for patients scheduled for surgery instead of crossmatching units for possible transfusion?

Increases donor unit availability in inventory

All of the following are consistent with graft-versus-host disease (GVHD) except:

“Immunologically naïve” T cell transplantation

In addition to nonhemolytic febrile transfusion reactions, what other indication exists for washed red blood cells?

IgA-deficient patients

What transfusion therapy is indicated for a patient who is found to be refractory to random platelets?

Apheresis platelets from an HLA-compatible donor

Four units of packed RBCs were used in the operating room at 3 PM. Can the remaining 2 units be returned to the blood bank at 5 PM?

Yes, if they are kept under proper storage conditions.

In anemia uncomplicated by low plasma proteins or shock, which of the following unit would be best?

Packed red cells

Which of the following is not reportable following a positive test?

T cruzi

A positive West Nile virus NAT test would warrant how long of a deferral?

120 days

Results of which test may be affected by use of citrated blood?

Treponema pallidum

Which of the following testing methods is used for confirmatory testing of suspected Treponema pallidum?

Fluorescent Treponemal Antibody Absorption (FTA-ABS)

Which of the following is only tested for once and not again after a negative?

Trypanosoma cruzi

How long is the deferral period following a positive Zika test?

4 weeks

How long is the deferral period following a positive Ebola test?

8 weeks

What is the purpose of adenine in blood units?

Increases ATP production

What role does dextrose have as an additive of units?

Substrate of ATP production

Irradiation is defined as what dose of gamma radiation to the central part of the unit?

25 Gy

Whole blood units are stored at 2–6C for how many days with all additives?

35 days

In a 155lb adult, one unit of whole blood will increase hematocrit by __% and hemoglobin by __ g/dL.

3, 1

Which of the following patients should not receive whole blood?

Woman with severe chronic anemia with compensated volume

250mL of packed red cells with additives have a hematocrit of…

55–65%

The trigger value to receive packed red cells is…

Hemoglobin of 8 g/dL

The form of platelets that will increase platelet count by 30–60K per unit is:

Single donor

Plasma may be stored at what temperature for 7 years with FDA approval?

-65C

Which form of plasma does not have therapeutic levels of factors V and VIII?

Thawed

Cryoprecipitate contains all of the following except:

Factor X