Differences in cell-surface marker expression
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6 Terms
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How can naïve and memory T cells be differentiated?
Through the form of the cell-surface T-cell signaling molecule CD45.
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What are the two isoforms of CD45?
CD45RA and CD45RO.
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Which CD45 isoform do naïve T cells express?
Naïve T cells express the CD45RA isoform.
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Which CD45 isoform do memory T cells express?
Memory T cells express the CD45RO isoform.
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Why is CD45RO important for memory T cells?
It is more efficient at signaling and initiating memory T-cell activation.
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What are some other cell-surface markers used to differentiate naïve and memory T cells?
Chemokine receptor CCR7
L-selectin (CD62L)
CD103
Note 
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