Hemostasis part 1

Vasoconstriction is caused by several regulatory molecules, which include:

Thromboxane A2 and Serotonin

Warfarin is classified as a vitamin K antagonist. The factors that are impacted by warfarin therapy are:

II, VII, IX, and X

When a pt is placed on warfarin therapy, the first factor that will be described is:

Factor VII

A pt with a positive family history of bleeding presents to the ED with the an aPTT of 29.5 and PT of 19.2. The pt is not on any medication and so is likely to deficient in what factor?

VII

Hageman factor (XII) is involved in each of the following reactions except:

Transformation of fibrinogen to fibrin

The most potent plasminogen activator in the contact phase of coagulation is:

Kallikrein

How does tissue factor pathway inhibitor inhibit coagulation?

Inhibition of tissue factor-factor VIIa-factor Xa complex

An inhibitor of plasmin activity is:

Alpha-2 antiplasmin

Antithrombin inhibits factors:

IIa and Xa

The propagation phase of the in vivo coagulation model includes:

A final burst of thrombin

In the cell-based model of coagulation the intrinsic pathway operates on the:

Activated platelet surface to produce the burst of thrombin

A new oral anticoagulant apixaban has been given to a patient who was previously on warfarin. This drug directly inhibits:

Factor Xa

The anticoagulant that directly inhibits thrombin is:

Argatroban

In secondary hemostasis, coagulation proteins become activated to form a fibrin clot. Prior to these proteins being activated, their inactive proenzymes are known as:

Zymogens

Alpha granules are found on the platelet in the:

Organelle Zone

Which of the following best represents the 3 steps of normal hemostasis (in order)?

Vasoconstriction, Platelet aggregation, Fibrin formation

Which of the following platelet antigens is the receptor for collagen?

GPIa/IIa complex

How does GPIb become activated in vivo and in vitro, respectively?

Shear Force, Ristocetin

A pt is diagnosed with a factor V Leiden mutation. The factor V activity level should be:

Within reference range

What factors are considered heat labile?

V and VIII

What factor serves as a carrier for factor VIII?

von Willebrand factor

Pts may present with either a bleeding or a thrombotic event in:

Dysfibrinogenemia

The key enemy of the fibrinolytic system is:

Plasmin

The major serine protease responsible for clot breakdown is:

TPA

What sub endothelial structural protein triggers coagulation through activation of FVII?

Tissue Factor

Protein C and its cofactor protein S proteolytically inactivate factors:

Va and VIIIa

Arterial thrombosis is caused by:

WBC and Platelets

The 2 factors that differentiate liver disease from vitamin K deficiency are:

V and VII

A hemophiliac male and a normal female can produce a:

Female carrier

Hemophilia B is a sex-linked recessive disorder that presents with decrease in factor:

IX

Acute disseminated intravascular coagulation is characterized by:

Hypofibrinogenemia

What is usually the factor VIII level in a hemophiliac patent with spontaneous bleeding?

<1%

What is the most common presentation of factor XIII deficiency?

Delayed bleeding tendency

A pt is diagnosed with amyloidosis, they will be deficient in which of the following factors?

Factor X

Which of the following tests are the most beneficial tool to aid in the diagnosis of DIC?

Thrombin Time, D-dimer, Fibrinogen

Pts with factor XIII deficiency have:

Delayed Bleeding

In hemolytic disease of the newborn, babies present with:

Hyperbilirubinemia

STOPPED ON PG 372 NUMBER 53