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1
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B

  1. Which of the following lacks a cell wall?
    A. Clostridium
    B. Mycoplasma
    C. Mycobacterium
    D. Nocardia
2
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D

  1. Which of the following are enzymes that damage the
    red blood cell?
    A. Lecithinase
    B. Endotoxins
    C. Protease
    D. Hemolysin
3
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A

  1. Which of the following do you expect to be the MOST
    resistant to high temperatures?
    A. Bacillus subtilis
    B. Neisseria gonorrhoeae
    C. Escherichia coli
    D. Staphylococcus aureus
4
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A

  1. A type of malnutrition associated with inadequate
    mastication, digestion, absorption, transport and
    excretion of nutrients.
    A. Primary malnutrition
    B. Under nutrition
    C. Secondary malnutrition
    D. Over-nutrition
5
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B

  1. Which of the following are identified world wide as
    "ESKAPE" pathogens?
    I. Enterococcus faecalis
    II. Acinetobacter baumannii
    III. Candida albicans
    IV. Pseudomonas aeruginosa
    A. I, II, III, IV
    B. I, II, and IV
    C. II, III and IV
    D. I, II, and III
6
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C

  1. Which of the following is the pathogen for smallpox?
    A. Plasmodium
    B. Aedes aegypti
    C. Variola virus
    D. Rubella virus
7
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A

  1. Group B staphylococcus that causes neonatal
    meningitis and sepsis?
    A. Streptococcus agalactiae
    B. Streptococcus pyogenes
    C. Staphylococcus aureus
    D. Staphylococcus epidermidis
8
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B

  1. What is the vector of a disease known as African
    Trypanosomiasis?
    A. Mosquitoes
    B. Tse-tse flies
    C. Lice
    D. Dust mites
9
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D

  1. Causative agent of food poisoning from canned
    goods.
    A. Corynebacterium diphtheriae
    B. Clostridium perfringens
    C. Gonococcus
    D. Clostridium botulinum
10
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A

  1. The capsule of Bacillus anthracis is composed of?
    A. D-glutamic acid
    B. Polysaccharide
    C. L-glutamic acid
    D. Nucleic acid
11
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D

  1. Patients with malaria should be asked about which of
    the following?
    A. Airdroplet transmission
    B. Sexual contact
    C. Eating of exotic foods
    D. Travelling to endemic areas
12
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C

  1. Which among the following is the organism that can
    grow at body temperature?
    A. Psychrophiles
    B. Thermophiles
    C. Mesophiles
    D. Acidophiles
13
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A

  1. In stained smear what looks like a Chinese letter
    arrangement having metachromatic granules? Infects
    the respiratory system.
    A. Corynebacterium diphtheriae
    B. Gonococcus
    C. Clostridium botulinum
    D. Clostridium perfringens
14
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D

  1. Promoting the "four o'clock habit", is all about the
    DOH program for prevention and control of which of the
    following disease?
    A. Malaria
    B. Malnutrition
    C. Tuberculosis
    D. Dengue
15
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C

  1. Which of the following indices represents the index
    that measures the number of individuals who have died
    within a susceptible population during a specific period
    because of a particular disease?
    A. Prevalence rate
    B. Virulence
    C. Mortality rate
    D. Morbidity rate
16
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D

  1. Which of the following indices refers to the measure
    of the number of individuals who become ill because of
    a specific disease within a susceptible population during
    a specific period?
    A. Morbidity ratio
    B. Prevalence rate
    C. Mortality rate
    D. Morbidity rate
17
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A

  1. Which of the following is NOT a primary sexually
    transmitted disease (STD)?
    A. Trypanosomiasis
    B. Genital herpes
    C. Gonorrhea
    D. Lymphogranuloma venereum
18
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A

  1. Primary Health Care pertains to ____?
    A. Immunization
    B. MRI/CT scan
    C. Cardiovascular stress test
    D. Bone densitometry
19
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C

  1. The following may be useful when performing
    microbiological assay of antibiotics, EXCEPT?
    A. Test tube inoculation
    B. Paper disc
    C. Staining method
    D. Cylinder plate
20
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C

  1. A trace mineral necessary for heme synthesis,
    electron transport and wound healing
    A. Manganese
    B. Chromium
    C. Copper
    D. Zinc
21
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A

  1. The bacterial organelle that is used for motility:
    A. Flagella
    B. Pili
    C. CIllia
    D. Pseudopods
22
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A

  1. The following are zoonotic disease, except:
    A. Mumps
    B. Anthrax
    C. Leptospirosis
    D. Brucellosis
23
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C

  1. The substance responsible for the heat resistance of
    endospores:
    A. Polymerized D-glutamic acid
    B. Flagellin
    C. Dipicolinic acid
    D. Teichoic acid
24
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D

  1. The diagnosis of early syphilis is best made by:
    A. Inoculating guinea pigs with lesion material and
    examining blood smears 3 days later
    B. Culture on chocolate agar and incubated with
    10% carbon dioxide
    C. The VDRL test
    D. Dark-field microscopy of lesion scrapings if a
    chancre is present
25
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B

  1. An object that is able to harbor and transmit
    microorganisms:
    A. Mite
    B. Fomite
    C. Arthropod
    D. Vector
26
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C

  1. A biological sterilization indicator used to test
    autoclave efficiency:
    A. Virus
    B. Bacillus thuringiensis
    C. Bacillus stearothermophilus
    D. Clostridium botulinum
27
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B

  1. The smallest known free-living microorganism is:
    A. Viruses
    B. Mycoplasma species
    C. Rickettsia
    D. Chlamydia
28
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B

  1. In microbial assay of antibiotics, what organism is
    used for penicillin G?
    A. Escherichia coli
    B. Staphylococcus aureus
    C. Bacillus subtilis
    D. Pseudomonas aeruginosa
29
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C

  1. Which one is not found in prokaryotic cell?
    A. Cell membrane
    B. Plasmids
    C. Mitochondria
    D. Chromosomes
30
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D

  1. Which of the following is a process of gene transfer
    where the carrier of DNA is a virus?
    A. Sporulation
    B. conjugation
    C. transformation
    D. transduction
31
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D

  1. Which of the following is the formation of dormant
    form of bacteria when conditions are inhospitable?
    A. Mutation
    B. Polymorphism
    C. Germination
    D. Sporulation
32
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C

  1. Regarding Pasteur's experiment with the S-neck
    flask, all of the following statements are true, EXCEPT
    _.
    A. All microorganisms were killed before
    beginning.
    B. There was food source involved.
    C. There was absence of air.
    D. Any possibility of contamination was removed
33
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D

  1. Which of the following is not gram-positive?
    A. Corynebacterium
    B. Bacillus
    C. Staphylococcus
    D. Treponema
34
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B

  1. Which of the following is the identified cause of
    Hansen's disease?
    A. Mycoplasma leprae
    B. Mycobacterium leprae
    C. Mycobacterium bovis
    D. Mycobacterium tuberculosis
35
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D

  1. Which of the following is NOT a fungus?
    A. Yeast
    B. Penicillium
    C. Molds
    D. Paramecium
36
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A

  1. How is avian flu or bird flu transmitted?
    A. Direct or indirect contact with infected birds
    B. Inhalation of contaminated aerosols
    C. Animal bites
    D. Mosquito bites
37
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B

  1. Which of the following is caused by an opportunistic
    pathogen for compromised systems?
    A. Trichomonas vaginalis
    B. Candida albicans
    C. Neisseria gonorrheae
    D. Herpes Simplex Virus
38
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D

  1. Which of the following substances can sterilize?
    A. Alcohols
    B. Chlorine
    C. Soap
    D. Ethylene oxide
39
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B

  1. Which of the following is NOT domain in the threedomain
    system?
    A. Archaea
    B. Animalia
    C. Bacteria
    D. Eukarya
40
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A

  1. Causative agent of typhoid fever is.
    A. Salmonella
    B. Aspergillus
    C. Shigella
    D. Rickettsia typhi
41
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A

  1. In gram staining, a bacterial cell that will stain pink to
    red, the specimen will be labeled as___.
    A. Gram negative
    B. Pink is not an observed color in gram stain
    C. Gram positive
    D. Gram variable
42
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A

  1. Which among the list is the spirochete causing
    leptospirosis?
    A. Leptospira interrogans
    B. Borell burgdorferi
    C. Treponema pallidum
    D. Mycobacterium leprae
43
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C

  1. Which causes athlete's foot?
    A. Tinea capitis
    B. Tinea corporis
    C. Tinea pedis
    D. Tinea cruris
44
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A

  1. Which of the following is NOT a characteristic/s of
    Neisseria?
    A. Requires X and V factors
    B. Oxidase-positive
    C. Cocci
    D. Gram-negative
45
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A

  1. Which type of industrial hazard includes ambient
    heat, burn, noise and vibration?
    A. Physical
    B. Chemical
    C. Global
    D. Biological
46
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D

  1. Which is due to thiamine deficiency?
    A. Cystitis
    B. Pellagra
    C. Stomatitis
    D. Beri-beri
47
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C

  1. Which component of milk has antibodies?
    A. Lactose
    B. Cream of milk
    C. Colostrum
    D. Fructose
48
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D

  1. Which of the following elements is associated to
    improve immune system?
    A. Sodium
    B. Chlorine
    C. Iodine
    D. Zinc
49
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B

  1. Choose the reservoir for chicken pox infection.
    A. Pigs
    B. Humans
    C. Chicken
    D. Cattles
50
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B

  1. Which of the following is common route of
    transmission for COVID-19, SARS and common cold?
    A. Needlestick injury
    B. Handshake
    C. Animal bites
    D. Contact with contaminated urine
51
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C

  1. What is the typical range of acceptance criteria for
    assay results as found in the labeled claim?
    A. 75-100%
    B. 85-95%
    C. 90-110%
    D. 100-110%
52
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D

  1. Which of the following is used in the analysis of
    aromatic compounds containing an amino group in the
    molecule?
    A. Acid-base titration
    B. Proximate assay
    C. Acetylation process
    D. Diazotization titration
53
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A

  1. Which of the following laws in Spectrometry express
    the mathematical relationship between light
    transmittance and thickness of the solution?
    A. Lambert or Bouger's Law
    B. Charles' Law
    C. Beer's Law
    D. Henry's Law
54
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A

  1. What is used for quantitative preparation of a
    standard solution?
    A. Volumetric flask
    B. Pipet
    C. Buret
    D. Graduated Cylinder
55
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A

  1. To control finished products in the warehouse of a
    company. What is the distribution practice?
    A. First in- First out
    B. First in last out
    C. First expiry first out
    D. Last in first out
56
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C

  1. The following may be useful when performing
    microbiological essay of antibiotics, EXCEPT?
    A. Test tube inoculation
    B. Paper disc
    C. Staining method
    D. Cylinder plate
57
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A

  1. Air contaminant causing death by asphyxiation in
    high concentration
    A. Carbon monoxide
    B. Lead
    C. Oxygen
    D. Carbon dioxide
58
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B

  1. Which of the pharmaceutical formulations will
    special methods like turbidimetric and nephelometric
    assays are applicable?
    A. Elixirs
    B. Suspensions
    C. Solutions
    D. Waters
59
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D

  1. Which of the following term refers to the
    characteristics of the drug product to retain its
    chemical, physical, therapeutic and toxicologic
    specification while inside its container?
    A. Shelf-life
    B. Quality
    C. Expiry date
    D. Stability
60
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D

  1. The period of the stability of a preparation is the time
    from the date of manufacture of the formulation until its
    biological or chemical activity is no less than how many
    percent of the labeled potency?
    A. 85%
    B. 95%
    C. 93%
    D. 90%
61
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A

  1. The United States Pharmacopeia (USP) content
    uniformity test is used to ensure which quality?
    A. Potency
    B. Bioequivalency
    C. Purity
    D. Toxicity
62
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B

  1. Techniques used in the test for the presence of
    bacterial endotoxins (BET) include the following,
    EXCEPT ____.
    A. Chromogenic technique
    B. Gasometric
    C. Gel-clot technique
    D. Turbidimetric technique
63
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C

  1. In what analytical process would Potentiometric A.
    Acid value determination method be MOST applicable?
    A. Acid value determination
    B. Biological assay
    C. pH determination
    D. moisture determination
64
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B

  1. Which among the statements defines the status of
    drug beyond expiration date?
    A. Lost 50% of drug activity
    B. Lost sufficient activity to be outside USP/NP
    monograph requirement
    C. Activity is below label claim
    D. Has lost 90% of activity
65
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A

  1. What is used in assessing efficiency of HEPA filter?
    A. DOP test
    B. Rodac plate test
    C. Bubble point test
    D. Powdered glass test
66
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B

  1. Widely used and preferred current assays of
    biological and pharmaceutical product is ____.
    A. TLC
    B. HPLC
    C. Gravimetric method
    D. GC
67
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A

  1. the following are units of measurements generally
    used inn spectrometry, EXCEPT____
    A. Milliliter
    B. Nanometer
    C. Micrometer
    D. Angstrom
68
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C

  1. In methods of analysis, which of the following refers
    to an expression of closeness of agreement between a
    series of measurements?
    A. Robustness
    B. Accuracy
    C. Precision
    D. Specificity
69
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B

  1. It is the partial or complete separation of the top or
    bottom of a tablet from the main body
    A. Lamination
    B. Capping
    C. Mottling
    D. Picking
70
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A

  1. Content uniformity test is to be performed for all
    tablet products whose active ingredient is:
    A. 50 mg or smaller
    B. 130-324 mg
    C. 324 mg or more
    D. 130 mg or less
71
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B

  1. An instrument used to measure the durability of
    tablets to shipping/transportation against shock and
    abrasion.
    A. Metal detector
    B. Friabilator
    C. Top loading balance
    D. Colorimeter
72
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D

  1. USP limit for tablet content uniformity:
    A. 90-110%
    B. 95-110%
    C. 90-100%
    D. 85-115%
73
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B

  1. The test used to determine the strength of tablets
    includes:
    A. Content uniformity
    B. Hardness
    C. Weight variation
    D. Both A and B
74
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B

  1. Determine the distance traveled by the solute, if its
    Rf value is 0.688 and the solvent travels 8.0 cm. the
    sample weight is 1.02 mg.
    A. 11.6 cm
    B. 5.5 cm
    C. 11.8 cm
    D. 0.70 cm
75
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B

  1. If the gram molecular weight of sulfuric acid is 98.
    Which of the following will be used to label the
    container of a solution containing 49 grams per liter of
    solution?
    A. 0.5N H2SO4
    B. 1N H2SO4
    C. 1M H2SO4
    D. 0.2M H2SO4
76
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B

  1. Caps, bottles, labels, and shipping containers are
    classified as what?
    A. accessories
    B. packaging materials
    C. drug products
    D. active components
77
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D

  1. When packaging and storage requirements specify a
    "hermetic container" it is understood that the
    A. Contents are protected from extraneous solids
    B. Contents are protected from extraneous solids and
    liquids
    C. Contents are protected from extraneous solids, liquids
    and vapors
    D. Contents are protected from extraneous solids,
    liquids, vapors and gas
78
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A

  1. The quality of pharmaceutical products is
    compromised by adulteration which may be brought
    about by the following EXCEPT?
    A. Weight variation
    B. Addition of another article
    C. Spoilage due to microorganisms
    D. Substitution of ingredients

79
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C

  1. The following are established product quality tests
    for injection solution EXCEPT _?
    A. Particulate Matter Content Determination
    B. Sterility Test
    C. Ash Content Determination
    D. pH Determination
80
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A

  1. Compute for the gram equivalent weight of MgO
    (mw=40.30)]
    A. 20.15
    B. 0.0403
    C. 0.403
    D. 0.2015
81
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B

  1. Which of the following assays will involve total
    alkaloidal determination?
    A. Specific
    B. Proximate
    C. Extraction
    D. Ultimate
82
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B

  1. Which of the following processes is NOT considered
    as a quality control (QC) function?
    A. Inspection of containers
    B. Inventory control
    C. In-process analysis
    D. Labeling ang packing materials
83
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D

  1. How much of the alkali solution will be required to
    neutralize 30 ml of the acid if 1 ml of HCl is equivalent to
    1.5 ml of 0.5N NaOH?
    A. 50 mL
    B. 40 mL
    C. 35 mL
    D. 45 mL
84
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C

  1. Which of the following statements will correctly
    define the total quality of a pharmaceutical product?
    A. Strict adherence to standards combines with quality
    B. Use of state-of-the-art equipment and advance
    technology means total quality.
    C. Quality is everybody's business in a pharmaceutical
    establishment.
    D. Production department is responsible for quality.
85
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C

  1. Koettsdorfer number is the common name for which
    of the following values?
    A. Ester value
    B. iodine value
    C. Saponification value
    D. acid value
86
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C

  1. What special instrumental method is used in the
    assay of thiamine?
    A. Colorimetry
    B. Refractometry
    C. Fluorimetry
    D. Potentiometry
87
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D

  1. What would be the most effective manner of
    cleaning glass apparatus?
    A. rinsing with nitric acid
    B. soaking in acetic
    C. soaking in detergent
    D. treatment with a solution of sodium chromate in
    sulfuric acid
88
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C

  1. Which of the following terms is used for the method
    of analysis done by separation of the constituent from
    the sample and then consequently weighing the
    product?
    A. Special method
    B. Volumetric method
    C. Gravimetric method
    D. Gasometric method
89
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B

  1. Which equation is used to predict the shelf life of a
    drug product?
    A. Michaelis Menten equation
    B. Arrhenius equation
    C. Hixson Crowell equation
    D. Stokes equation
90
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C

  1. Pharmaceutical products of good quality and
    acceptability should possess or exhibit following
    characteristics, EXCEPT ____
    A. Therapeutically effective
    B. Free of adulterants
    C. Cheap price
    D. Safe
91
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B

  1. Good manufacturing practice (GMP) as part of quality
    assurance simply means _
    A. Personnel must be properly trained
    B. About getting things right all along the line
    C. Environmental cleanliness and hygiene must be
    observed
    D. All records and documentation must be in place
92
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A

  1. What constitutes the stationary phase used in thin
    layer chromatography (TLC)?
    A. Silica gel
    B. Aqueous salt solution
    C. Alumina
    D. Cellulose
93
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B

  1. What chemical reaction is involved during analysis
    wherein there occur a change of valence of reacting
    substances?
    A. Neutralization
    B. Oxidation- reduction
    C. Complexation
    D. Precipitation
94
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C

  1. Water content determination Method 2
    A. Gravimetry
    B. Titrimetry
    C. Azeotropic Method
    D. Karl Fischer Method
95
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A

  1. These are chemicals used to prevent one element
    from interfering in the analysis of another element
    A. masking agents
    B. demasking agents
    C. auxiliary complexing agent
    D. indicator
96
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D

  1. If the sample of beeswax has an acid value of 18.45
    and ester value of 74, what is the saponification number
    of the sample?
    A. 85%
    B. 88%
    C. 98%
    D. 92%
97
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D

  1. To find the gram equivalent weight of Phosphoric
    acid, divide its molecular weight by:
    A. 1
    B. 0
    C. 2
    D. 3
98
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C

  1. The direct or residual titrimetric determination of
    organic or inorganic acids using an accurately measured
    volume of base:
    A. Acidimetry
    B. Precipitimetry
    C. Alkalimetry
    D. Oxidimetry
99
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A

  1. Solutions containing all the reagents and solvents
    used in the analysis, but no deliberately added analyte.
    A. Blank solution
    B. Solution with sample
    C. Standard solution
    D. Test solution
100
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A

  1. The most widely employed acid-base titration is for
    organic nitrogen
    A. Kjeldahl analysis
    B. Titrimetric analysis
    C. Potentiometric analysis
    D. Chromatographic analysis