Clinical Chemistry Lecture Exam III

MLS 4410

Acute intermittent porphyria (AIP) patients have a deficiency of:

PBG-deaminase

Zinc protoporphyrin measurements are useful to assess blood concentrations of:

Lead

Which of the following is likely to occur first in iron deficiency anemia?

Decreased serum ferritin

Which of the following proteins binds ferric iron and is increase in IDA?

Transferrin

The majority of the iron in whole blood is:

Bound to hemoglobin

The majority of absorbed lead is taken up by __ and inhibits heme synthesis:

Erythrocytes

Maple syrup urine disease is characterized by an increase in valine, leucine, and isoleucine due to a decrease or absence in:

Alpha-ketoacid decarboxylase

The best treatment for aminoacidopathies like PKU is an…

Decreased protein diet

When measuring AA concentrations in plasma, it is recommended that the patient be…

Fasting

Which of the following is a tumor marker for hepatocellular carcinoma?

Alpha 1-fetoprotein

What protein concentration is often low in Wilson’s disease?

Ceruloplasmin

Which cardiac marker is elevated the longest period after myocardial infarction (MI)?

Troponin T

Which isoenzyme of CK is primarily found in cardiac muscle?

MB

Which of the following cardiac markers is the first to increase after an acute myocardial infarction?

Myoglobin

Which MI marker is the most specific and sensitive and remains elevated for 14 days or more?

TnT

The SGOT test is another name for analyzing…

AST

Which liver enzyme is most significantly affected by specimen hemolysis?

LDH

Which liver enzyme is most closely associated with liver damage due to alcohol consumption?

GGT

A patient with mumps has elevated amylase. How should this be interpreted?

Caused by parotitis from mumps

An individual comes into the emergency room with a crush injury. Which enzyme would be significantly increased?

CK

A hallmark of which aminoacidopathy is the formation of crystals and stones in urine:

Cystinuria

Transthyretin is also known as…

Prealbumin

A deficiency in this protein increases the risk of emphysema:

Alpha 1-antitrypsin

A pregnant woman at 32 weeks gestation’s vaginal secretions have fFN. What does this indicate?

Pre-term labor

Which of the following albumin:globulin ratio would be considered normal?

1.2

Which of the following conditions is indicated by presence of Bence-Jones proteins?

Multiple myeloma

In what condition would you monitor BNP values?

Left ventricular failure