Immune Cell Origins (Innate + Adaptive)

Where do immune cells originate from?

Bone Marrow

What types of progenitor stem cells are in the bone marrow?

Hematopoietic

What pluripotent cells can rise from hematopoietic stem cells?

1. Myeloid Progenitors

2. Lymphoid Progenitors

What cells are differentiated from myeloid progenitors?

1. Leukocytes

2. Red Blood Cells

3. Platelets

What affects the behavior of stem cells in the bone marrow?

Stromal Cells

What are the functions of stromal cells?

1. Secrete growth factors

2. Display molecule on cell surface

What is the biggest difference between innate and adaptive immunity?

Memory

Which immunity uses these cells?:

1. Dendritic Cells

2. NK Cells

3. Phagocytes

4. Epithelial Barriers

5. Complements

Innate

Which immunity uses these cells?:

1. T Cells

2. B Cells

Adaptive

Where do adaptive immune cells develop?

Primary Lymphoid Organs

In which lymphoid organ do T cells develop?

Thymus

In which lymphoid organ do B cells develop?

Bone Marrow

Where does B cell recombination (VDJ Recombination) occur?

Bone Marrow

What activates B cells and T cells?

Pathogens in secondary lymphoid organs

What are the secondary lymphoid organs?

1. Lymph Node

2. Spleen

What is the theory that explains lymphocyte differentiation?

Clonal Selection Theory

What are the steps of clonal selection?

1. Progenitor cells produce many lymphocytes

2. Self-reactive and immature lymphocytes removed

3. Foreign antigen chooses lymphocyte

4. Selected lymphocyte divides/differetiates

In what phase does clonal selection happen?

Lag Phase

What cytokine does clonal selection require?

IL-22