ethanol metabolism

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6 Terms

1
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where is ethanol absorbed?

intestine

2
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where can we find ethanol receptors

in the brain

3
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what chemical coumound gives toxic hangover

acetaldehyde

4
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what enzyme catalyzes the conversion of ethanol→acetaldehyde

alcohol dehydrogenase

  • produce NADH 

5
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How does ethanol metabolism interfere with glucose production 

ethanol inhibits gluconeogenesis by decreasing steady concentration of pyruvate as a decrease of NAD+/NADH ratio

  • fats in the liver become acetyl CoA but it wont be able to enter krebs beacuse there is not enough OA because of high NADH

  • Produce ketone bodies

  • fatty liver 

6
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Asian-flush syndrome

Due to a mutation in the ALDH2 enzyme; ALDH22

  • decreased capacity for acetaldehyde metabolism so it accumulates → vasodilation causes red face & have symptoms of nausea, headache etc.