Biochemistry Quiz 3

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Myoglobin's function depends on what 2 things?

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Biology

52 Terms

1

Myoglobin's function depends on what 2 things?

ability to bind to oxygen ability to release oxygen where and when needed

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2

Is binding of a protein and ligand reversible?

Yes

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3

What is the symbol for the association constant?

Ka

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4

coordinated set of interactions among many classes of proteins, molecules, and cell types

immune response

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5

white blood cells

leukocyte

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6

what are the 2 complementary systems of the immune response

humoral and cellular immune system

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7

what does the humoral immune system do and what type of cells?

directed at bacterial infections and extracellular viruses, B cells

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8

What does the cellular immune system do and what type of cells?

destroys infected host cells, parasites, and foreign tissues, T cells

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9

First line of defense

innate immunity

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10

what kind of immunity is nonspecific

innate immunity

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11

what kind of immunity is specific

adaptive immunity

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12

what type of immunity produces B cell antibodies

adaptive

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13

what type of immunity produces white blood cells (natural killer cells)

innate

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14

What type of immunity has memory functions

adaptive

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15

what 2 types of cells are in the cellular immune response

Cytotoxic T cells and Helper T cells

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16

What type of cell produce soluble signaling proteins called cytokines

Helper T cells

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17

What type of cell recognizes infected cells or parasites by using cell receptors on its surface

Cytotoxic T cells

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18

antibodies are also called

immunoglobulins

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19

immunoglobulins do what?

bind bacteria, viruses, and other foreign molecules and target them for destruction

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20

what type of cell produces antibodies/ immunoglobulins?

B cells

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21

How many heavy and light chains does an immunoglobulin have?

2 of each

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22

How many domains does an immunoglobulin have?

12

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23

How many subunits does an immunoglobulin have?

4

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24

How many domains are constant in the immunoglobulins?

8

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25

Why are there domains in the immunoglobulins that vary?

Because these are the antigen binding sites

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26

The Fab regions do what?

bind antigen (1 site per branch)

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27

Fc region does what

facilitate biological activity

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28

what motif is found in immunoglobulins?

immunoglobulin fold

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29

the antibody hinge region is rich in what

proline (to prevent globular folding)

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30

molecule or pathogen capable of eliciting an immune response

antigen

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31

small molecules that can elicit an immune response when covalently attached to large proteins

hapten

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32

antibodies or T cell receptors bind to this part of the antigen

epitope

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33

what type of forces facilitate contact between antibody and antigen

non covalent

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34

conformational changes in the antibody and/or antigen allow the complementary groups to interact fully

induced fit

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35

contain a mixture of antibodies that recognize different parts of the protein

polyclonal antibodies

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36

produced by injecting a protein into an animal

polyclonal antibodies

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37

homogeneous, all recognizing the same epitope.

monoclonal antibodies

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38

Synthesized by a population of identical B cells (a clone)

monoclonal antibodies

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39

2 antibody techniques

ELISA and Western blot/ immunoblot

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40

ELISA stand for what?

Enzyme-linked Immunosorbent Assay

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41

Helicobacter pylori is a gram positive or gram negative bacteria?

gram negative

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42

In the primer article Ha et. al, how many trimeric structures are there in of H. Pylori urease.

4 trimeric units

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43

In Ha et al. how many domain(s) are/is there in the beta subunit of each trimeric unit.

2 domain per beta subunit

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44

In Ha et al. where do they say the active site/s are located?

in the alpha subunit (1 per unit)

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45

How many active sites are there in H. Pylori Urease?

12

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46

How many alpha and beta subunits are there in one trimeric unit?

Each trimeric unit is composed of 3 monomers. Each monomer has 1 alpha and 1 beta. Thus in a trimeric unit there are 3 alphas and 3 betas.

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47

What is attached at the c-terminus of the beta subunit?

amino acids for the formation of the trimer

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48

H. Pylori urease is what kind of assembly?

dodecameric

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49

What did they do in the Ha et al. paper?

Crystalized H. Pylori and determined its structure.

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50

Urease activity _____ over time when in the presence of AHA (inhibitor)

decreases

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51

When urease is not paired with AHA (inhibitor), the the amount of ammonia _____ the longer it is incubated?

increases

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52

What type of cells does the humoral response use?

B cell/ immunoglobulins

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