Alpha 1 blockers and Centrally acting alpha 2 agonsits

What is Alpha 1 recpeptors

Gq for smooth muscle contraction

What is Alpha 2 do

Gi

Inhibittory

Which drugs are Alpha 1 adrenergic blockers

Prazosin

Doxazosin

Terazosin

Which drugs are alpha 2 agonists 

Clondine

Methyldopa

What is the order of receptor affinity for alpha receptors

Epi

Norepi

Isoprotre

What is the order for receptor affinity for Beta receptors

Isopro

Epineph

Norepineph

What happens alpha recpetors are stimulated 

Arteries constrict

What body responses does Alpha 1 lead to

Smooth Muscle contraction

Vasoconstriction in vessels

Contraction of pylorus and urethral sphinter decreased digestion and urination

Pupillary dilation

What is the prototype for alpha blockers

Prazosin

What are the effects of Prazosin

Reduction in total periphery resistance and mean BP by selectively inhibiting alpha 1 receptors

What are the adverse effects of Prazosin

Postural Hypotension

Is Prazosin used alon

No with a diuretic or beta blocker

What is the first dose effect of prazosin

Syncopy and depression

What is the MOA of Terazosin

Dual function to treat HTn alpha 1 blocker and relax prostate smooth muscle 

What are some interactions of alpha 1 blockers

Hypotension

interacts with highly protein bound drugs

What is Alpha Methyldopa

Prodrug

What is the MOA of Alpha Methyl Dopa

acts on alpha 2 receptors in brain and inhibits adrenergic discharge in the medulla

When is Alpha-methyldopa used

Hypertension during pregnancy

What is Clonidine

Partial agonist of central alpha 2 receptor

What is the MOA of Clonidine

Uses feedback mechanism to shut down norepinephrine 

Which drug minimizes nicotine and narcotic withdrawal symptoms

Clonidine

What is the MOA of Methyldopa

Creates false norepinpehrine to make it inactive