Lec 25 Intro to immune system

Innate immune system

Innate immune system

Fast reaction to general antigens

Does not improve if re exposed

Activates adaptive

Adaptive immune system

Slower response to specficic antigens

Memory

What cells are in the innate immune system

Macrophages

Neutrophils

Dendritic cells

Eosinophils

Mast cells/basophils

Natural killer cells

Macrophages

—>First responders

—>activated by complement system and PAMPs via TLRs

—>Phagocytosis, APCs, secrete cytokines,

—>Produce lipid mediators

Neutrophils

—>First cells that arrive in mass numbers

—>Activated by TLRs, complement system, TNF-alpha, interleukins

—>Pahgocytosis, secrete cytokines

Dendritic cels

Activated by TLRs

Phagocytosis, APCs, secrete cytokines

Eosinophils

—>Activated by IL5, Ige

—>Kill parasites, secrete cytokines

Mas cells/basophils

—>Activated by C3a, C5a, IgE

—>Secrete histamine and cytokines

Natural killer cells

—>Type of innate lymphoid cell

—>Recognize aletered self

—>Apoptosis

Adaptive immune system componenets

B cells make antibodies

T cells= cytotoxic, helper, regulatory

Immunoglobulins

2 light and 2 heavy chains

Varaible region

Constant region

Class switching (switch from M & D)

T cells

MHC 1 presents to CD8+ (cytotoxic) T cells

MHC2 presents to CD4+ (helper) T cells