chapter 4 review questions

tissues and organs associated with hematopoietic system include

• bone marrow

• fetal liver

• lymph nodes and thymus

the normal sequence of blood cell development is

yolk sac → liver / splee → red bone marrow

maturation sequence of the thrombocyte (platelet) is

megakaryoblast → promegakaryocyte → megakaryocyte → thrombocyte

maturational sequence of erythrocyte

rubriblast - prorubricyte - rubricyte - metarubricyte - reticulocyte - erythrocyte

pronormoblast - basophilic normoblast - polychromatophilic normoblast - orthochromic normoblast - reticulocyte - erythrocyte

cell maturation sequence of segmented neutrophils

myeloblast - promyelocyte - myelocyte - metamyelocyte - band / stab - segmented neutrophil (pmn)

hematopoietically active area of bone marrow is

red marrow

bone marrow represents approx _ of total body weight and avg 1500gms in adults

3.5 - 6 %

by age 18 , red marrow can be found in the

skull bones

vertebrae and ribs

sternum and pelvis

when body reverts back to extramedullary hematopoiesis, abnormal conditions in the bone marrow such as _ can be present

hemolytic or aplastic anemias

infiltration by malignant cells

overproliferation of cell line

stem cells are functionally define at the single cell level as

having the capacity for self renewal

having the capacity of multipotential differentiation

mapc stands for

multipotent adult progenitor cells

erythropoiesis occurs in specialized niches (erythropoietic niches) where erythroid precursors can

proliferate

differentiate

enucleate

erythroid cells account ofr _ of nucleated cells in normal bone marrow

5 - 38%

during granulopoiesis, mature cells spend an average of _ in the proliferating pool

3 -6 d

once in the blood circulation, granulocytes have an avg lifespan of

6 -10 h

myeloid cells account for _ of the nucleated cells in normal bone marrow

23 - 85%

macrophages in the bone marrow patients with gaucher’s dz have _ in the cytoplasm

uncatabolized glucocerebosides

tern interleukin used to describe

• a group of protein molecules

• cytokines

  • molecules that influence blood cell proliferation, matruarion, migration, and adhesion

major role of hematopoietic growth factors appears to be regulating

• the proliferation of hpcs

• differentiation of hpcs

• survival and function of mature blood cells

as a blood cell matures, the overall cell diameter in most cases

decr

as blood cell matures, the ratio of nucleus to cytoplasm (n:c) in most cases

decr

the chromatin pattern in most cells as the cell matures

becomes more clumped

presence of nucleoli is assoc w

immature cells

in the blast stage of development of leukocytes, the cytoplasm of cell is

light blue and lacks granules

characteristic segmented neutrophil is

the greatest number of wbcs in the peripheral blood of adult

characteristic of mature monocyte is

kidney bean shaped nucleus

characteristic of a mature lymphocyte is

light, sky-blue cytoplasm

characteristic of a band form neutrophil is

light, sky blue cytoplasm

characteristic of a mature eosinophil is

large orange granules