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IgG
Most abundant in blood; provides long-term immunity; crosses the placenta to protect the fetus
IgA
Found in mucosal areas (respiratory, digestive, urogenital tracts); protects against pathogens in secretions like saliva, tears, and breast milk.
IgM
First antibody produced in an immune response; excellent at forming antigen-antibody complexes.
IgE
Involved in allergic reactions and defense against parasites; binds to mast cells and basophils.
IgD
Functions mainly as a receptor on immature B cells; role in initiating B cell activation.