caspi et al "short 5-htt"

aim

investigate role of short 5-htt allele on mdd

method

longitudinal, prospective, interviews, surveys, genotype

procedure

847 new zealanders assessed every other year for mhd until 21. 5 years later surveyed on sle from passed 5 years and assessed again. group 1: 2 short, group 2: 1 long 1 short, group 3: 2 long alleles.

results

those with one or more short alleles showed more symptoms of mdd especially if 3 or more sle experienced.

link

supports genetic predisposition to mdd. sle and short allele resulted in increased risk of mdd supporting gene environment interaction.